This 2011 randomized, double-blind, placebo-controlled trial published in The American Journal of Medicine (DOI: 10.1016/j.amjmed.2010.08.005, PMID: 21187189) evaluated the effects of alpha-lipoic acid (ALA) supplementation on body weight in 360 obese adults over 20 weeks. Participants were assigned to receive either 1200 mg or 1800 mg of ALA daily, or
