This 2004 randomized controlled trial evaluated the effects of a high-soy-protein, low-fat diet on body composition in overweight and obese individuals. Ninety participants with a BMI between 27.5 and 35 were assigned to one of three groups: lifestyle education only (LE-G), soy-based diet without exercise (SD-G), or soy-based diet with
This 2023 randomized, double-blind, placebo-controlled crossover study evaluated the acute effects of a ready-to-drink (RTD) thermogenic beverage on resting energy expenditure (REE), hemodynamic function, and subjective outcomes in 28 healthy adults (14 males, 14 females; mean age 23.3 years). Participants consumed either the RTD beverage containing 360 mg of caffeine
This 2021 randomized, double-blind, placebo-controlled clinical trial evaluated the effects of daily supplementation with 500 mg of CGA-7™, a standardized green coffee bean extract rich in chlorogenic acid isomers, over 12 weeks in 71 healthy overweight adults (BMI 25–30 kg/m²). The CGA-7 group showed significant reductions in body weight, BMI,
This 2017 randomized, double-blind, placebo-controlled crossover trial evaluated the effects of α-lipoic acid (ALA) supplementation on body weight in overweight or obese individuals. A total of 103 Chinese Han participants with a BMI ≥25 kg/m² were randomized to receive either 1200 mg/day of ALA or placebo for 8 weeks, followed
This 2016 randomized controlled trial assessed the impact of meal-based protein enhancement on weight loss and physical function in 67 obese adults aged ≥60 with functional limitations. Participants were assigned to either a traditional weight loss diet or one with >30g protein per meal. Both groups experienced significant weight loss
This 2013 randomized controlled trial evaluated the efficacy of extracorporeal shockwave therapy (ESWT) in 70 patients with knee osteoarthritis (KOA). Participants were randomized to receive either ESWT (n=34; 4000 pulses at 0.25 mJ/mm² weekly for 4 weeks) or placebo (n=36; sham treatment at 0 mJ/mm²). Outcomes were assessed at baseline,
This randomized controlled trial evaluated the dose-dependent effects of radial extracorporeal shock wave therapy (rESWT) on knee osteoarthritis (KOA) in 89 patients. Participants were assigned to one of four treatment groups varying in shock intensity (0.12 mJ/mm² or 0.24 mJ/mm²) and number of impulses (2,000 or 4,000), or to a
This randomized, open-label, multicenter study evaluated the efficacy of a 0.2% caffeine-based topical solution compared to the standard 5% minoxidil solution in 210 male patients with androgenetic alopecia over a 6-month period. The primary endpoint was the percentage change in the proportion of anagen hairs, assessed via frontal and occipital
This 2022 randomized controlled trial compared the effects of three emollient creams—urea-glycerol cream (UGC), glycerol cream (GC), and paraffin cream (PC)—on skin barrier function in adults with atopic dermatitis (AD). Over four weeks, UGC significantly improved skin barrier integrity, reduced transepidermal water loss (TEWL), and increased natural moisturizing factor (NMF)
This Phase 1/2 double-blind, placebo-controlled trial assessed the safety and efficacy of intravenous allogeneic umbilical cord-derived mesenchymal stem cells (UC-MSCs) in 30 patients with chronic stable heart failure and reduced ejection fraction (HFrEF) under optimal medical therapy. Patients were randomized to receive a single infusion of UC-MSCs (1×10^6 cells/kg) or
