Well Referenced

Tag: obesity

The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials

This 2020 systematic review and meta-analysis evaluated the effects of berberine supplementation on obesity-related parameters, inflammation, and liver function enzymes. Analyzing 12 randomized controlled trials, the study found that berberine intake led to significant reductions in body weight (mean difference: -2.07 kg), body mass index (BMI), waist circumference, and C-reactive

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June 26, 2025 No Comments

Effects of oral α-lipoic acid administration on body weight in overweight or obese subjects: a crossover randomized, double-blind, placebo-controlled trial

This 2017 randomized, double-blind, placebo-controlled crossover trial evaluated the effects of α-lipoic acid (ALA) supplementation on body weight in overweight or obese individuals. A total of 103 Chinese Han participants with a BMI ≥25 kg/m² were randomized to receive either 1200 mg/day of ALA or placebo for 8 weeks, followed

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June 26, 2025 No Comments

Insufficient sleep predicts poor weight loss maintenance after 1 year

This 2023 randomized controlled trial investigated the impact of sleep duration and quality on weight loss maintenance in adults with obesity. After an initial 8-week low-calorie diet resulting in an average weight loss of 13.1 kg, participants were monitored over a 1-year maintenance phase. Those with short sleep duration (5)

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June 26, 2025 No Comments

Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1): a randomised, double-blind, placebo-controlled, phase 3 trial

The 2023 OASIS 1 trial evaluated the efficacy and safety of oral semaglutide 50 mg daily in 667 adults with overweight or obesity without type 2 diabetes. Over 68 weeks, participants receiving semaglutide experienced a mean weight loss of 15.1%, compared to 2.4% with placebo. Notably, 85% of the semaglutide

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June 26, 2025 No Comments

Bone Health After Exercise Alone, GLP-1 Receptor Agonist Treatment, or Combination Treatment: A Secondary Analysis of a Randomized Clinical Trial

This 2024 secondary analysis of a randomized clinical trial examined the effects of exercise, GLP-1 receptor agonist (liraglutide) treatment, and their combination on bone health in adults with obesity. After an initial 8-week low-calorie diet, 195 participants were randomized into four groups: exercise alone, liraglutide alone, combination of both, or

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June 26, 2025 No Comments

Histamine and the Regulation of Body Weight

This review article explores the role of histamine as a central neurotransmitter in regulating appetite and metabolism. Histamine exerts anorexigenic effects primarily through H₁ receptor stimulation, mediating leptin’s inhibitory impact on appetite and potentially delaying leptin resistance in high-fat diet-induced obesity. Additionally, histamine may enhance lipolysis, contributing to weight regulation.

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June 26, 2025 No Comments

Lipid-lowering effect of berberine in human subjects and rats

This 2012 pilot study assessed the lipid-lowering effects of berberine in obese human subjects and Sprague-Dawley rats. Participants received 500 mg of berberine orally three times daily for 12 weeks. In humans, berberine administration resulted in a significant reduction in triglyceride levels by 23% and total cholesterol by 12.2%, along

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June 26, 2025 No Comments