weight loss Archives - Well Referenced

The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials

This 2020 systematic review and meta-analysis evaluated the effects of berberine supplementation on obesity-related parameters, inflammation, and liver function enzymes. Analyzing 12 randomized controlled trials, the study found that berberine intake led to significant reductions in body weight (mean difference: -2.07 kg), body mass index (BMI), waist circumference, and C-reactive

June 26, 2025 No Comments

Effects of oral α-lipoic acid administration on body weight in overweight or obese subjects: a crossover randomized, double-blind, placebo-controlled trial

This 2017 randomized, double-blind, placebo-controlled crossover trial evaluated the effects of α-lipoic acid (ALA) supplementation on body weight in overweight or obese individuals. A total of 103 Chinese Han participants with a BMI ≥25 kg/m² were randomized to receive either 1200 mg/day of ALA or placebo for 8 weeks, followed

June 26, 2025 No Comments

Improved Function With Enhanced Protein Intake per Meal: A Pilot Study of Weight Reduction in Frail, Obese Older Adults

This 2016 randomized controlled trial assessed the impact of meal-based protein enhancement on weight loss and physical function in 67 obese adults aged ≥60 with functional limitations. Participants were assigned to either a traditional weight loss diet or one with >30g protein per meal. Both groups experienced significant weight loss

June 26, 2025 No Comments

Weight loss without losing muscle mass in pre-obese and obese subjects induced by a high-soy-protein diet

This 2004 randomized controlled trial evaluated the effects of a high-soy-protein, low-fat diet on body composition in overweight and obese individuals. Ninety participants with a BMI between 27.5 and 35 were assigned to one of three groups: lifestyle education only (LE-G), soy-based diet without exercise (SD-G), or soy-based diet with

June 26, 2025 No Comments

Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1): a randomised, double-blind, placebo-controlled, phase 3 trial

The 2023 OASIS 1 trial evaluated the efficacy and safety of oral semaglutide 50 mg daily in 667 adults with overweight or obesity without type 2 diabetes. Over 68 weeks, participants receiving semaglutide experienced a mean weight loss of 15.1%, compared to 2.4% with placebo. Notably, 85% of the semaglutide

June 26, 2025 No Comments

Bone Health After Exercise Alone, GLP-1 Receptor Agonist Treatment, or Combination Treatment: A Secondary Analysis of a Randomized Clinical Trial

This 2024 secondary analysis of a randomized clinical trial examined the effects of exercise, GLP-1 receptor agonist (liraglutide) treatment, and their combination on bone health in adults with obesity. After an initial 8-week low-calorie diet, 195 participants were randomized into four groups: exercise alone, liraglutide alone, combination of both, or

June 26, 2025 No Comments

Hibiscus sabdariffa extract inhibits obesity and fat accumulation, and improves liver steatosis in humans

This 2014 randomized controlled trial assessed the effects of Hibiscus sabdariffa extract (HSE) on obesity and liver steatosis in overweight individuals (BMI ≥27). Over 12 weeks, participants consuming HSE exhibited significant reductions in body weight, BMI, body fat, waist-to-hip ratio, and serum free fatty acids compared to controls. Imaging studies

June 26, 2025 No Comments

The Effects of Metformin or Orlistat on Obese Women with Polycystic Ovary Syndrome: A Prospective Randomized Open-Label Study

This 2011 prospective randomized open-label study compared the effects of metformin and orlistat on hormonal profiles, lipid parameters, and ovulation rates in 80 obese women with PCOS over a 3-month period. Both treatments led to significant reductions in body weight, BMI, and waist circumference, with no significant difference between the

June 26, 2025 No Comments

The Role of Orlistat Combined with Lifestyle Changes in the Management of Overweight and Obese Patients with Polycystic Ovary Syndrome

This 2014 prospective study evaluated the effects of combining orlistat (120 mg three times daily) with lifestyle modifications (low-calorie diet and exercise) over six months in 101 women with PCOS and 29 BMI-matched controls. Both groups experienced significant BMI reductions. In the PCOS group, there were notable improvements in insulin

June 26, 2025 No Comments

Chronic Oxytocin Administration Inhibits Food Intake, Increases Energy Expenditure, and Produces Weight Loss in Fructose-Fed Obese Rhesus Monkeys

This 2015 study investigated the effects of chronic oxytocin (OT) administration on weight loss in diet-induced obese (DIO) male rhesus monkeys. Over a 4-week period, monkeys received subcutaneous OT injections at escalating doses (0.2 mg/kg for 2 weeks, then 0.4 mg/kg for 2 weeks). Results showed a significant reduction in

June 26, 2025 No Comments

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