Well Referenced

Tag: Randomized Controlled Trials

Anti-inflammatory effects of oral supplementation with curcumin: a systematic review and meta-analysis of randomized controlled trials

This systematic review and meta-analysis examined the anti-inflammatory effects of curcumin supplementation, incorporating data from 32 randomized controlled trials with 2,038 participants. The analysis showed significant reductions in several inflammatory markers, including C-reactive protein, interleukin-6, tumor necrosis factor-alpha, and interleukin-8, as well as an increase in interleukin-10. Curcumin supplementation also

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June 26, 2025 No Comments

Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials

This systematic review and meta-analysis examined the effects of curcumin/turmeric supplementation on inflammatory and oxidative stress markers across 66 randomized controlled trials. The results showed significant reductions in C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6), along with improvements in total antioxidant capacity (TAC), superoxide dismutase (SOD) activity,

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June 26, 2025 No Comments

Methylene Blue: Magic Bullet for Vasoplegia?

This systematic review evaluates the use of methylene blue (MB) in managing vasoplegic shock, particularly in critical care, liver transplantation, and cardiac anesthesia. While MB has shown consistent blood pressure improvement in small studies and case reports, its effect on mortality and oxygen delivery remains inconclusive. The review stresses the

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June 26, 2025 No Comments

The efficacy of platelet rich plasma in the treatment of erectile dysfunction: a systematic review and meta-analysis of randomized controlled trials

This meta-analysis evaluated the efficacy of platelet-rich plasma (PRP) therapy in treating erectile dysfunction (ED) by analyzing four randomized controlled trials (RCTs) with 413 participants. PRP therapy significantly improved erectile function compared to placebo, as measured by the International Index of Erectile Function (IIEF) scores at one, three, and six

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June 26, 2025 No Comments

The potential role of intracavernosal injection of platelet-rich plasma for treating patients with mild to moderate erectile dysfunction: A GRADE-Assessed systematic review and meta-analysis of randomized controlled trials

This systematic review and meta-analysis evaluated the efficacy and safety of intracavernosal platelet-rich plasma (PRP) injections for treating mild to moderate erectile dysfunction (ED), analyzing three randomized controlled trials with 221 patients. The PRP group showed significant improvements in erectile function based on the International Index of Erectile Function-Erectile Function

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June 26, 2025 No Comments

The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials

This meta-analysis reviewed data from nine randomized controlled trials with 911 participants to assess the effects of L-carnitine supplementation on weight loss. The findings indicate that L-carnitine supplementation led to a statistically significant weight reduction, with participants losing an average of 1.33 kg more than control groups (p=0.005). However, there

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June 26, 2025 No Comments

Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document

The article titled “Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document” examines the inconsistent benefits of levothyroxine (LT4) and liothyronine (LT3) combination therapy for hypothyroidism, despite its widespread use due to patient-reported benefits. A joint conference by the American, British, and European Thyroid Associations reviewed clinical evidence

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June 26, 2025 No Comments

Evaluating the efficacy and safety of platelet-rich plasma injection for erectile dysfunction: a systematic review and meta-analysis of randomized controlled trials

This meta-analysis systematically reviewed three randomized controlled trials (RCTs) involving 230 patients to evaluate the efficacy and safety of platelet-rich plasma (PRP) injections for erectile dysfunction (ED). PRP treatment significantly improved erectile function, with patients showing a greater mean improvement in International Index of Erectile Function (IIEF) scores (MD, 2.99;

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June 26, 2025 No Comments

Dehydroepiandrosterone (DHEA) for Depression: A Systematic Review and Meta-Analysis

The meta-analysis titled “Dehydroepiandrosterone (DHEA) supplementation for depression: a systematic review and meta-analysis” (Psychoneuroendocrinology, 2018, PMID: 30124161) examined the efficacy of DHEA supplementation for reducing depressive symptoms across multiple randomized controlled trials. The findings indicated that DHEA supplementation demonstrated a moderate antidepressant effect and was generally well-tolerated, though mild side

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June 26, 2025 No Comments