Well Referenced

Tag: Randomized Controlled Trials

Serious adverse events reported in placebo randomised controlled trials of oral naltrexone: a systematic review and meta-analysis

This systematic review and meta-analysis evaluated the safety profile of oral naltrexone by analyzing serious adverse events (SAEs) reported in placebo-controlled randomized controlled trials (RCTs). A total of 89 RCTs involving 11,194 participants across various conditions—including alcohol use disorders, psychiatric disorders, impulse control disorders, obesity, Crohn’s disease, fibromyalgia, and cancer—were

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June 26, 2025 No Comments

Which supplements can I recommend to my osteoarthritis patients?

This 2018 review analyzed systematic reviews and randomized controlled trials to evaluate the efficacy of various oral supplements for osteoarthritis (OA). The findings indicate limited but promising evidence supporting the use of Boswellia serrata extract, Pycnogenol, curcumin, and methylsulfonylmethane (MSM) in alleviating OA symptoms. Despite the generally poor quality of

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June 26, 2025 No Comments

Testosterone replacement therapy and the risk of venous thromboembolism: A systematic review and meta-analysis of randomized controlled trials

This 2021 systematic review and meta-analysis evaluated the association between testosterone replacement therapy (TRT) and venous thromboembolism (VTE) risk by analyzing 13 randomized controlled trials encompassing 5,050 men. The pooled data indicated no significant increase in VTE risk among men receiving TRT compared to placebo (RR: 1.03; 95% CI: 0.49–2.14;

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June 26, 2025 No Comments

Effect of garlic on the components of metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials

This meta-analysis reviewed the effects of garlic supplementation on components of metabolic syndrome, including cholesterol levels, blood glucose, blood pressure, and inflammation. The results showed that garlic significantly reduced total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol. It also led to decreases in fasting blood glucose and systolic

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June 26, 2025 No Comments

Effects of silymarin supplementation on liver and kidney functions: A systematic review and dose-response meta-analysis

This meta-analysis reviewed the effects of silymarin supplementation on liver and kidney functions by analyzing data from 41 randomized controlled trials. The results showed significant reductions in liver enzymes (alkaline phosphatase, alanine transaminase, aspartate aminotransferase) and creatinine levels, as well as increased serum glutathione levels. Longer-duration and higher-dose silymarin supplementation

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June 26, 2025 No Comments

Hawthorn extract for treating chronic heart failure

This systematic review assessed the effects of hawthorn extract as an adjunctive treatment for chronic heart failure (CHF), analyzing data from 14 randomized, double-blind, placebo-controlled trials involving 855 patients. The findings showed that hawthorn extract significantly improved exercise tolerance, increased maximal workload, reduced the pressure-heart rate product, and alleviated symptoms

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June 26, 2025 No Comments

Is Curcumin Intake Really Effective for Chronic Inflammatory Metabolic Disease? A Review of Meta-Analyses of Randomized Controlled Trials

This systematic review analyzed 54 meta-analyses of randomized controlled trials to assess the effectiveness of curcumin supplementation in managing chronic inflammatory metabolic diseases. Curcumin was found to significantly reduce inflammatory markers like CRP, IL-6, and TNF-α; lower oxidative stress (as indicated by decreased MDA); and improve glucose metabolism (reducing FBG,

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June 26, 2025 No Comments

Inflammation, Frailty and Cardiovascular Disease

This meta-analysis demonstrated that subcutaneous semaglutide significantly reduced body weight by up to 14.9%, improved glycemic control with an average HbA1c reduction of 1.7%, and had a manageable safety profile dominated by gastrointestinal side effects. It involved over 1,961 participants, predominantly adults with obesity, and highlighted semaglutide’s potential to enhance

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June 26, 2025 No Comments

Randomized controlled trials investigating the relationship between dietary pattern and high-sensitivity C-reactive protein: a systematic review

This systematic review, published in 2019 in Nutritional Reviews (DOI: 10.1093/nutrit/nuz003), analyzed 56 randomized controlled trials to investigate the effects of various dietary patterns on high-sensitivity C-reactive protein (hsCRP) levels, a marker of systemic inflammation linked to cardiovascular risk. The review examined diets such as low-fat, low-carbohydrate, Mediterranean, Portfolio, Paleolithic,

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June 26, 2025 No Comments