Well Referenced

Tag: Randomized Controlled Trials

Dehydroepiandrosterone (DHEA) supplementation for cognitive function

The systematic review titled “Dehydroepiandrosterone (DHEA) supplementation for cognitive function in healthy elderly individuals” (Cochrane Database of Systematic Reviews, 2001, DOI: 10.1002/14651858.CD000304) analyzed data from three randomized controlled trials with a total of 145 healthy participants aged 55 and older. The review found no significant cognitive benefits from DHEA supplementation

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June 26, 2025 No Comments

Effects of Hyperbaric Oxygen Therapy on Long COVID: A Systematic Review

This systematic review analyzed ten clinical studies, including randomized controlled trials and observational studies, to evaluate the effects of hyperbaric oxygen therapy (HBOT) on long COVID symptoms. The findings suggest that HBOT may improve quality of life, fatigue, cognition, neuropsychiatric symptoms, and cardiopulmonary function in long COVID patients. However, the

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June 26, 2025 No Comments

Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials

This pooled analysis of four randomized controlled trials examined the sex-specific effects of dehydroepiandrosterone (DHEA) therapy on bone mineral density (BMD) and body composition in older adults. The study found that DHEA supplementation led to a 1.0% increase in lumbar spine BMD in women over 12 months, while men experienced

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June 26, 2025 No Comments

Efficacy of Micronized Progesterone for Sleep: A Systematic Review and Meta-analysis of Randomized Controlled Trial Data

A 2021 systematic review and meta-analysis published in the Journal of Clinical Endocrinology & Metabolism (PMID: 33245776) assessed the impact of micronized progesterone on sleep outcomes, particularly in postmenopausal women. The study analyzed nine randomized controlled trials with a total of 388 participants. Results indicated that micronized progesterone improved sleep

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June 26, 2025 No Comments

Estrogen-containing hormone therapy and Alzheimer’s disease risk: understanding discrepant inferences from observational and experimental research

This 2006 study explores the conflicting findings from observational research and randomized controlled trials regarding the effects of estrogen-containing hormone therapy (HT) on Alzheimer’s disease (AD) risk. Observational studies have often suggested a protective effect of HT against AD, while randomized trials, such as the Women’s Health Initiative Memory Study,

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June 26, 2025 No Comments