Well Referenced

Tag: postmenopausal women

Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study

This randomized controlled trial evaluated the efficacy and safety of a topical solution combining 0.25% finasteride and 3% minoxidil versus 3% minoxidil alone in 30 postmenopausal women with female pattern hair loss (FPHL) over 24 weeks. The combination therapy significantly improved hair diameter (p = 0.039) and reduced serum dihydrotestosterone

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June 26, 2025 No Comments

Choline intake in a large cohort of patients with nonalcoholic fatty liver disease

This observational study examined the relationship between dietary choline intake and liver fibrosis severity in patients with nonalcoholic fatty liver disease (NAFLD). The findings revealed that postmenopausal women with lower choline intake had significantly worse fibrosis (p=0.002), even after adjusting for factors such as age, obesity, triglycerides, diabetes, alcohol use,

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June 26, 2025 No Comments

Nutritional genomics: defining the dietary requirement and effects of choline

This review article explores how genetic variations affect choline metabolism and dietary requirements. It highlights that men and postmenopausal women are more likely to experience liver or muscle dysfunction when deprived of dietary choline, while premenopausal women may resist choline deficiency due to estrogen-induced expression of the PEMT gene, which

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June 26, 2025 No Comments

Clinically relevant changes in sexual desire, satisfying sexual activity and personal distress as measured by the profile of female sexual function, sexual activity log, and personal distress scale in postmenopausal women with hypoactive sexual desire disorder

This randomized controlled trial evaluated the effectiveness of transdermal testosterone therapy (TTP) in postmenopausal women with hypoactive sexual desire disorder (HSDD), demonstrating significant improvements in sexual desire, satisfying sexual activity (SSA), and reductions in personal distress. The study identified clinically meaningful changes, with responder rates in the testosterone group being

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June 26, 2025 No Comments

Dehydroepiandrosterone sulfate and postmenopausal women

The systematic review titled “Dehydroepiandrosterone (DHEA) supplementation for women in the peri- or postmenopausal phase” (Current Opinion in Obstetrics and Gynecology, 2011, PMID: 21478748) assessed the benefits and safety of DHEA supplementation in peri- and postmenopausal women. Oral DHEA supplementation showed limited and inconsistent benefits, with mild improvements in bone

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June 26, 2025 No Comments

DHEA therapy for women: effect on sexual function and wellbeing

The review article “DHEA therapy for women: effect on sexual function and wellbeing” (Human Reproduction Update, 2007, PMID: 17208951) examines the effects of dehydroepiandrosterone (DHEA) supplementation on sexual function, cognition, and overall well-being in women. The findings suggest that DHEA modestly improves bone mineral density when combined with other treatments

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June 26, 2025 No Comments

Effect of exogenous estrogen on serum pregnenolone, cortisol, and androgens in postmenopausal women

The observational study titled “Effect of exogenous estrogen on serum pregnenolone, cortisol, and androgens in postmenopausal women” (Obstetrics & Gynecology, 1975, PMID: 163457) examined how estrogen therapy influences adrenal steroidogenesis in postmenopausal women. The study found that exogenous estrogen significantly increased serum levels of pregnenolone, cortisol, and androgens, suggesting that

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June 26, 2025 No Comments

Two to three years of hormone replacement treatment in healthy women have long-term preventive effects on bone mass and osteoporotic fractures: the PERF study

This study investigated the long-term benefits of short-term hormone replacement therapy (HRT) on bone health in postmenopausal women. A total of 347 healthy postmenopausal women participated in placebo-controlled trials, receiving either HRT or placebo for 2-3 years. Follow-up assessments conducted 5, 11, or 15 years after discontinuation showed that women

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June 26, 2025 No Comments