The observational study titled "Effect of exogenous estrogen on serum pregnenolone, cortisol, and androgens in postmenopausal women" (Obstetrics & Gynecology, 1975, PMID: 163457) examined how estrogen therapy influences adrenal steroidogenesis in postmenopausal women. The study found that exogenous estrogen significantly increased serum levels of pregnenolone, cortisol, and androgens, suggesting that
