Two to three years of hormone replacement treatment in healthy women have long-term preventive effects on bone mass and osteoporotic fractures: the PERF study

This study investigated the long-term benefits of short-term hormone replacement therapy (HRT) on bone health in postmenopausal women. A total of 347 healthy postmenopausal women participated in placebo-controlled trials, receiving either HRT or placebo for 2-3 years. Follow-up assessments conducted 5, 11, or 15 years after discontinuation showed that women