Well Referenced

Tag: postmenopausal women

Effect of Exercise Intensity on Abdominal Fat Loss During Calorie Restriction in Overweight and Obese Postmenopausal Women: A Randomized, Controlled Trial

This 2009 randomized controlled trial investigated the impact of aerobic exercise intensity on abdominal fat loss in 112 overweight and obese postmenopausal women. Participants were assigned to one of three 20-week interventions with equal energy deficits: calorie restriction alone (CR only), CR plus moderate-intensity aerobic exercise (CR+moderate), or CR plus

Read More »
June 26, 2025 No Comments

Estrogen-alone therapy and invasive breast cancer incidence by dose, formulation, and route of delivery: findings from the WHI observational study

This 2018 analysis from the Women’s Health Initiative Observational Study evaluated the relationship between estrogen-alone hormone therapy and invasive breast cancer incidence among 26,525 postmenopausal women with a hysterectomy. Over an average follow-up of 8.2 years, the study found no significant differences in breast cancer risk when comparing low-dose (

Read More »
June 26, 2025 No Comments

The evidence base for HRT: what can we believe?

This 2017 review critically examines the evolving evidence surrounding hormone replacement therapy (HRT) in postmenopausal women. It highlights the initial perception of HRT as a low-risk intervention for symptom relief and chronic disease prevention, which was challenged by the early termination of the Women’s Health Initiative (WHI) trial due to

Read More »
June 26, 2025 No Comments

Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomised trial

This 2012 randomized controlled trial assessed the long-term impact of hormone replacement therapy (HRT) on cardiovascular outcomes in 1,006 recently postmenopausal women aged 45–58. Participants received either HRT (17β-estradiol with or without norethisterone acetate) or no treatment and were followed for 10 years of therapy plus 6 years post-intervention. The

Read More »
June 26, 2025 No Comments

Androgen therapy in women: for whom and when

This 2013 review discusses the clinical use of androgen therapy in women, particularly for those experiencing hypoactive sexual desire disorder (HSDD). It highlights the role of androgens in sexual function, behavior, and cognition, noting that adrenal androgens may influence sexual symptoms and cognitive function in postmenopausal women. The article emphasizes

Read More »
June 26, 2025 No Comments

Type and Timing of Menopausal Hormone Therapy and Breast Cancer Risk: Individual Participant Meta-Analysis of the Worldwide Epidemiological Evidence

This 2019 meta-analysis by the Collaborative Group on Hormonal Factors in Breast Cancer pooled individual data from over 108,000 postmenopausal women with breast cancer and more than 400,000 without, across 58 studies worldwide, to evaluate the impact of menopausal hormone therapy (MHT) on breast cancer risk. The analysis found that

Read More »
June 26, 2025 No Comments

Effects of subdermal implants of estradiol and testosterone on the endometrium of postmenopausal women

This 2007 retrospective study evaluated the endometrial effects of combined estradiol and testosterone subdermal implants in 258 postmenopausal women over two years. Endometrial thickness was monitored via ultrasonography, and hysteroscopic biopsies were performed in cases of thickening (>5 mm). Among 44 women with endometrial thickening, histological analysis revealed endometrial polyps

Read More »
June 26, 2025 No Comments

Effect of a Multi-Ingredient Based Food Supplement on Sexual Function in Women with Low Sexual Desire

This exploratory, prospective, non-controlled observational study assessed the efficacy of Libicare®, a multi-ingredient food supplement, in improving sexual function among 29 postmenopausal women aged 45–65 with low sexual desire (FSFI < 25.83). Participants consumed two tablets daily for two months. Libicare® contains extracts of Trigonella foenum-graecum, Turnera diffusa, Tribulus terrestris,

Read More »
June 26, 2025 No Comments