This 2011 prospective cohort study assessed the impact of combined estradiol and testosterone implants on bone mineral density (BMD) in postmenopausal women. Sixty-one participants were divided into two groups: 34 women received hormone implants, while 27 did not undergo hormonal therapy. Over one year, the implant group maintained or slightly
This observational study examined associations between various demographic, lifestyle, and dietary factors and systemic inflammation markers in adults aged 50–76 years. Higher age and BMI were linked to increased levels of most inflammation markers, while physical activity, dietary vitamin C, fiber intake, and omega-3 fatty acids were associated with lower
This review discusses the potential benefits of hormone replacement therapy (HRT), particularly testosterone and growth hormone (GH), in maintaining physical function in older men, especially those suffering from age-related declines in muscle mass and strength (sarcopenia). It highlights that while exercise is important, it may not be sufficient for older
The article “Might DHEA be considered a beneficial replacement therapy in the elderly?” explores the potential benefits of dehydroepiandrosterone (DHEA) supplementation as a hormone replacement therapy for age-related hormonal decline. DHEA levels naturally decrease with age, leading to physiological changes that may impact overall health. The study suggests that DHEA
A six-month study evaluated the effects of daily 100 mg dehydroepiandrosterone (DHEA) supplementation in elderly men and women, finding that DHEA and DHEA sulfate (DS) levels increased, accompanied by a higher DS/cortisol ratio. In women, the treatment led to increased levels of potent androgens comparable to those of younger individuals,
This randomized controlled trial evaluated the effectiveness of transdermal testosterone therapy (TTP) in postmenopausal women with hypoactive sexual desire disorder (HSDD), demonstrating significant improvements in sexual desire, satisfying sexual activity (SSA), and reductions in personal distress. The study identified clinically meaningful changes, with responder rates in the testosterone group being
This prospective cohort study examined the association between combined estrogen and testosterone therapy and the risk of invasive breast cancer in postmenopausal women. Over 24 years, 4,610 cases of invasive breast cancer were identified, with current users of estrogen plus testosterone therapies showing a 2.5-fold increased risk compared to never
The observational study titled “Effect of exogenous estrogen on serum pregnenolone, cortisol, and androgens in postmenopausal women” (Obstetrics & Gynecology, 1975, PMID: 163457) examined how estrogen therapy influences adrenal steroidogenesis in postmenopausal women. The study found that exogenous estrogen significantly increased serum levels of pregnenolone, cortisol, and androgens, suggesting that
The article “Is DHEA replacement beneficial in chronic adrenal failure?” examines the effects of dehydroepiandrosterone (DHEA) supplementation in patients with adrenal insufficiency, a condition leading to androgen deficiency, particularly in women. The study suggests that DHEA replacement may positively influence mood, sexuality, and subjective health status, although the effects vary
This study presents a hypothesis on the potential benefits of early, low-dose hormone replacement therapy (HRT) in healthy perimenopausal women, particularly in improving metabolic syndrome components and reducing cardiovascular risk. However, the article does not provide empirical data to support these claims and is based purely on theoretical assumptions. It
