Well Referenced

Category: Vitamins, Supplements & Antioxidants

Nutritional support for disease prevention and cellular health.

The Effect of 600 mg Alpha-lipoic Acid Supplementation on Oxidative Stress, Inflammation, and RAGE in Older Adults with Type 2 Diabetes Mellitus

This quasi-experimental study examined the effects of 600 mg/day alpha-lipoic acid (ALA) supplementation for six months on oxidative stress, inflammation, and RAGE levels in 135 sedentary older adults with type 2 diabetes mellitus (T2DM). The study found a statistically significant decrease (p < 0.05) in 8-isoprostane levels and RAGE concentrations

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June 26, 2025 No Comments

Green tea and red light–a powerful duo in skin rejuvenation

This study explores the combined effects of green tea and red light therapy on skin rejuvenation. Participants who applied green tea to their skin for 20 minutes daily followed by red light therapy with a central wavelength of 670 nm showed significant improvements in skin texture, reduction in wrinkles, and

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June 26, 2025 No Comments

Oxidation events and skin aging

This review examines how oxidative stress, primarily caused by UV exposure, contributes to skin aging, including the degradation of collagen and the formation of reactive oxygen and nitrogen species. It emphasizes the skin’s adaptive response to oxidative stress and the role of antioxidants in mitigating damage. Understanding these mechanisms is

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June 26, 2025 No Comments

Alpha lipoic acid inhibits proliferation and epithelial mesenchymal transition of thyroid cancer cells

This in vitro study investigated the effects of alpha-lipoic acid (ALA) on thyroid cancer cell proliferation, migration, and invasion. Using four human thyroid cancer cell lines (BCPAP, HTH-83, CAL-62, and FTC-133), researchers found that ALA significantly suppressed cancer cell proliferation by activating the AMPK pathway, leading to the downregulation of

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June 26, 2025 No Comments

Alpha-Lipoic Acid and Diabetic Neuropathy

This review article explores the role of alpha-lipoic acid (ALA) in managing diabetic peripheral neuropathy, highlighting its antioxidant properties and therapeutic potential. ALA reduces oxidative stress, enhances reduced glutathione levels, and protects nerves from hyperglycemia-induced damage. Clinical trials have demonstrated that 600 mg of ALA daily, administered either intravenously or

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June 26, 2025 No Comments

Alpha-lipoic acid as a new treatment option for Alzheimer’s disease–a 48 months follow-up analysis

This observational study examined the long-term effects of alpha-lipoic acid (ALA) supplementation in Alzheimer’s disease (AD) patients over 48 months. Participants received 600 mg of ALA daily, which appeared to slow cognitive decline compared to the typical progression of AD, as measured by the Mini-Mental State Examination (MMSE). ALA’s antioxidant

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June 26, 2025 No Comments

Decrypting the potential role of α-lipoic acid in Alzheimer’s disease

The article titled “Decrypting the potential role of α-lipoic acid in Alzheimer’s disease” (Life Sciences, 2021, PMID: 34450170) reviews the neuroprotective effects of alpha-lipoic acid (α-LA) in Alzheimer’s disease (AD), which is characterized by amyloid-β plaques, tau protein accumulation, oxidative stress, and mitochondrial dysfunction. The review highlights α-LA’s antioxidant, antiapoptotic,

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June 26, 2025 No Comments

A Review of the Use of Biotin for Hair Loss

This systematic review evaluated the efficacy of biotin supplementation for hair and nail growth, analyzing 18 case reports involving patients with conditions such as biotinidase deficiency, uncombable hair syndrome, and brittle nail syndrome. All cases showed clinical improvement with biotin supplementation, but there is no strong evidence supporting its routine

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June 26, 2025 No Comments