Well Referenced

Category: Vitamins, Supplements & Antioxidants

Nutritional support for disease prevention and cellular health.

Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study

The study titled “Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study” (PMID: 17604563) investigated the effects of 600 mg/day alpha-lipoic acid (ALA) supplementation over three months on individuals with peripheral arterial disease (PAD). This randomized controlled trial found that ALA improved walking tolerance and delayed the

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June 26, 2025 No Comments

Anti-aging protective effect of L-carnitine as clinical agent in regenerative medicine through increasing telomerase activity and change in the hTERT promoter CpG island methylation status of adipose tissue-derived mesenchymal stem cells

This in vitro study explored the anti-aging effects of L-carnitine (LC) on adipose tissue-derived mesenchymal stem cells (ADSCs), demonstrating that LC significantly increased telomerase activity, reduced cellular senescence, and altered the methylation status of CpG islands in the hTERT promoter, which regulates telomerase expression. These findings suggest LC could enhance

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June 26, 2025 No Comments

A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection

This randomized controlled trial evaluated the efficacy of acetyl-L-carnitine (ALC) in treating antiretroviral toxic neuropathy in HIV-1 patients through a multicenter, double-blind, placebo-controlled design. The study found that ALC significantly improved neuropathic symptoms compared to placebo, suggesting its potential as a therapeutic option to enhance quality of life and treatment

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June 26, 2025 No Comments

Protective effects of alpha-lipoic acid on bleomycin-induced skin fibrosis through the repression of NADPH Oxidase 4 and TGF-β1/Smad3 signaling pathways

This study explores the protective effects of alpha-lipoic acid (ALA) on bleomycin-induced skin fibrosis in a rat model, focusing on its role in reducing oxidative stress and inflammation. ALA treatment significantly decreased skin thickness and hydroxyproline content, indicating reduced fibrosis severity. Biochemical analyses showed ALA lowered malondialdehyde (MDA) levels, a

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June 26, 2025 No Comments

B Vitamins and the Brain: Mechanisms, Dose and Efficacy–A Review

The review article titled “B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review” by David O. Kennedy, published in Nutrients in 2016 (PMID: 26828517), examines the essential roles of the eight B-vitamins in brain function, highlighting their involvement in energy production, DNA/RNA synthesis and repair, methylation processes, and the

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June 26, 2025 No Comments

Intravenous vitamin C in the treatment of allergies: an interim subgroup analysis of a long-term observational study

This study evaluates the use of intravenous vitamin C (Pascorbin®) for managing allergy symptoms, showing significant reductions in both disease-specific and nonspecific symptoms like fatigue, depression, and sleep issues in 71 allergy patients. The treatment proved beneficial as an adjunct therapy, with no reported adverse effects. The observational study suggests

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June 26, 2025 No Comments

The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial

The study titled “The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial” (Diabetes Care, 2003, PMID: 12610036) is a randomized controlled trial investigating the effects of alpha-lipoic acid (ALA) on diabetic polyneuropathy. Involving 120 patients with type 2 diabetes and symptomatic polyneuropathy, participants received either

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June 26, 2025 No Comments

A Double-blind, Placebo-controlled Study Evaluating the Efficacy of an Oral Supplement in Women with Self-perceived Thinning Hair

This observational study analyzed the use of intravenous vitamin C (Pascorbin®) in treating allergy symptoms, showing significant improvements in both disease-specific and nonspecific symptoms like fatigue and depression in 71 patients. The treatment had no adverse effects and demonstrated potential as an adjunct therapy for allergies. These findings suggest vitamin

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June 26, 2025 No Comments