Well Referenced

Category: Vitamins, Supplements & Antioxidants

Nutritional support for disease prevention and cellular health.

Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat.

This study titled “Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat” provides compelling evidence that glutathione (GSH), a key antioxidant, is actively transported into the brain through a specific, saturable, carrier-mediated mechanism rather than by passive diffusion. Using carotid artery injection in rats, 35S-labeled glutathione

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June 26, 2025 No Comments

Glutathione redox imbalance in brain disorders

The article titled “Glutathione redox imbalance in brain disorders” reviews the critical role of glutathione (GSH), a major antioxidant, in the pathophysiology of various neuropsychiatric and neurodegenerative disorders, including autism, schizophrenia, bipolar disorder, Alzheimer’s disease, and Parkinson’s disease. It highlights evidence from both animal and human studies showing decreased levels

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June 26, 2025 No Comments

Glutathione dysregulation and the etiology and progression of human diseases

The article “Glutathione Dysregulation and the Etiology and Progression of Human Diseases” explores how disruptions in glutathione (GSH) balance contribute to the onset and development of numerous diseases, including cancer, neurodegenerative conditions, cardiovascular disorders, inflammatory and immune diseases, metabolic syndromes, and age-related illnesses. Glutathione is critical in maintaining redox homeostasis

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June 26, 2025 No Comments

Nebulized Glutathione as a Key Antioxidant for the Treatment of Oxidative Stress in Neurodegenerative Conditions

Nebulized glutathione (GSH), a powerful intracellular antioxidant, shows promise as a novel therapy for combating oxidative stress in neurodegenerative conditions such as Parkinson’s and Alzheimer’s disease. Acting through its sulfhydryl group, GSH neutralizes reactive oxygen and nitrogen species, supports mitochondrial function, regulates apoptosis and autophagy, and activates the NRF2 antioxidant

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June 26, 2025 No Comments

Glutathione Improves the Antioxidant Activity of Vitamin C in Human Lens and Retinal Epithelial Cells: Implications for Vitreous Substitutes

This study titled “Glutathione Improves the Antioxidant Activity of Vitamin C in Human Lens and Retinal Epithelial Cells: Implications for Vitreous Substitutes” investigated the synergistic antioxidant effects of glutathione and vitamin C on human ocular cells. Researchers found that glutathione not only protects against the cytotoxicity of vitamin C at

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June 26, 2025 No Comments

Glutathione levels are associated with methotrexate resistance in acute lymphoblastic leukemia cell lines

This study explores how intracellular glutathione (GSH) levels contribute to methotrexate (MTX) resistance in acute lymphoblastic leukemia (ALL) cell lines. Using metabolomic and gene expression analysis across 13 ALL lines, researchers found elevated GSH levels were associated with MTX resistance, indicating a constitutive metabolic defense mechanism. Key genes involved in

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June 26, 2025 No Comments

Glutathione!

This article provides a comprehensive overview of glutathione, a critical antioxidant composed of cysteine, glycine, and glutamic acid, found in cells at concentrations similar to glucose and potassium. It exists in reduced (GSH) and oxidized (GSSG) forms, with the GSH/GSSG ratio serving as a marker of cellular redox status—typically over

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June 26, 2025 No Comments

High-dose intravenous glutathione in man. Pharmacokinetics and effects on cyst(e)ine in plasma and urine

This randomized, double-blind, placebo-controlled trial evaluated the effects of intravenous glutathione in 30 patients with alcoholic liver disease (ALD). Patients treated with glutathione showed statistically significant improvements in liver enzyme levels—specifically reductions in GGT, AST, and ALT—indicating reduced liver inflammation and oxidative stress. The therapy was well-tolerated, with no significant

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June 26, 2025 No Comments

Anemia in Older Adults

This review article discusses the evaluation and management of anemia in older adults, a condition associated with increased morbidity and mortality. It highlights that anemia is frequently asymptomatic but can present with fatigue, weakness, or shortness of breath. Common causes include iron deficiency, chronic kidney disease, inflammation, and gastrointestinal blood

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June 26, 2025 No Comments

Impact of Glutathione and Vitamin B-6 in Cirrhosis Patients: A Randomized Controlled Trial and Follow-Up Study

This review article explores the glutathione (GSH) system as a promising therapeutic target in neurological and neuropsychiatric disorders, highlighting its vital role in maintaining redox balance, reducing oxidative stress, and modulating neuroinflammation. Disruptions in GSH metabolism are linked to conditions such as schizophrenia, bipolar disorder, autism, Alzheimer’s, Parkinson’s, and major

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June 26, 2025 No Comments