Nutritional support for disease prevention and cellular health.
This 2021 review published in Current Opinion in Clinical Nutrition and Metabolic Care (PMID: 34138767) examines the structure, function, and clinical relevance of intestinal permeability (aka “leaky gut”). It highlights how dietary and inflammatory factors can disrupt the intestinal barrier, while nutrients such as vitamins A and D, zinc, glutamine,
This 2021 animal study published in Frontiers in Physiology (DOI: 10.3389/fphys.2021.582223, PMCID: PMC8009994) evaluated the cardioprotective effects of lipoic acid, zinc, and clopidogrel in Wistar rats with isoproterenol-induced myocardial infarction (MI). The study found that pre-treatment with these agents reduced mortality rates, ventricular arrhythmias, ST-segment elevation, and CK-MB levels. Lipoic
This 2014 review published in Neurobiology of Aging (DOI: 10.1016/j.neurobiolaging.2013.10.073, PMID: 24246717) explores how aging—a primary risk factor for Parkinson’s disease (PD)—can be managed through targeted nutritional compounds, including alpha-lipoic acid, acetyl-L-carnitine, coenzyme Q10, and melatonin. These agents support mitochondrial energy metabolism, enhance antioxidant defenses, and modulate gene expression via
This study explores how intracellular glutathione (GSH) levels contribute to methotrexate (MTX) resistance in acute lymphoblastic leukemia (ALL) cell lines. Using metabolomic and gene expression analysis across 13 ALL lines, researchers found elevated GSH levels were associated with MTX resistance, indicating a constitutive metabolic defense mechanism. Key genes involved in
This article provides a comprehensive overview of glutathione, a critical antioxidant composed of cysteine, glycine, and glutamic acid, found in cells at concentrations similar to glucose and potassium. It exists in reduced (GSH) and oxidized (GSSG) forms, with the GSH/GSSG ratio serving as a marker of cellular redox status—typically over
This randomized, double-blind, placebo-controlled trial evaluated the effects of intravenous glutathione in 30 patients with alcoholic liver disease (ALD). Patients treated with glutathione showed statistically significant improvements in liver enzyme levels—specifically reductions in GGT, AST, and ALT—indicating reduced liver inflammation and oxidative stress. The therapy was well-tolerated, with no significant
This review article discusses the evaluation and management of anemia in older adults, a condition associated with increased morbidity and mortality. It highlights that anemia is frequently asymptomatic but can present with fatigue, weakness, or shortness of breath. Common causes include iron deficiency, chronic kidney disease, inflammation, and gastrointestinal blood
This review article explores the glutathione (GSH) system as a promising therapeutic target in neurological and neuropsychiatric disorders, highlighting its vital role in maintaining redox balance, reducing oxidative stress, and modulating neuroinflammation. Disruptions in GSH metabolism are linked to conditions such as schizophrenia, bipolar disorder, autism, Alzheimer’s, Parkinson’s, and major
The 2015 article “Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application” (Journal of Nutrition and Metabolism, PMID: 26167297) reviews how various foods and nutrients influence the body’s detoxification systems, particularly phase I cytochrome P450 enzymes, phase II conjugation enzymes, Nrf2 signaling, and
This randomized, double-blind, placebo-controlled crossover study evaluated the effects of nebulized glutathione (GSH) on airway responsiveness in eight patients with mild asthma. While GSH is known for its antioxidant properties, nebulized administration (600 mg in saline) caused significant bronchoconstriction, with a 19% drop in FEV1 and a 61% increase in
