Well Referenced

Category: Vitamins, Supplements & Antioxidants

Nutritional support for disease prevention and cellular health.

Efficacy of Intravenous Magnesium Sulfate in the Treatment of Acute Migraine Attacks

This 2001 randomized controlled trial evaluated the effectiveness of intravenous magnesium sulfate in treating acute migraine attacks. Thirty patients were enrolled; those who received 1 g of magnesium over 15 minutes experienced significant improvements—86.6% became pain-free, and 100% reported relief from accompanying symptoms, compared to minimal improvement in the placebo

Read More »
June 26, 2025 No Comments

Enhancement of learning and memory by elevating brain magnesium

This 2010 in vitro and animal study demonstrated that elevating brain magnesium levels using magnesium-L-threonate (MgT) significantly improved learning and memory in rats, including enhanced short- and long-term memory, working memory, and pattern completion in aged rats. The improvements were linked to increased synaptic density in the hippocampus and enhanced

Read More »
June 26, 2025 No Comments

Essential elements in depression and anxiety. Part I

This 2014 review article explores the roles of essential elements—zinc, magnesium, lithium, iron, calcium, and chromium—in the development and treatment of depression and anxiety. It highlights evidence from preclinical and clinical studies linking deficiencies in these elements to mood disorders and notes that supplementation may improve the efficacy of antidepressants

Read More »
June 26, 2025 No Comments

Influence of Pectin Structural Properties on Interactions with Divalent Cations and Its Associated Functionalities

This in vitro study review investigates how the structural properties of pectin—a plant-derived polysaccharide—affect its interactions with divalent cations like calcium and zinc. Key factors influencing binding include pectin’s degree of methylesterification, molecular weight, and the distribution of galacturonic acid units, along with environmental variables such as pH and cation

Read More »
June 26, 2025 No Comments

Evaluating the Effect of Magnesium and Magnesium Plus Vitamin B6 Supplement on the Severity of Premenstrual Syndrome

This randomized controlled trial investigated the effects of magnesium alone and in combination with vitamin B6 on premenstrual syndrome (PMS) severity in women attending health centers in Isfahan, Iran. After a two-month PMS symptom tracking phase, participants were randomized to receive either magnesium, magnesium plus vitamin B6, or a placebo

Read More »
June 26, 2025 No Comments

Medicinal Plants and Phytochemicals Regulating Insulin Resistance and Glucose Homeostasis in Type 2 Diabetic Patients: A Clinical Review

This systematic review evaluates the effects of medicinal plants and phytochemicals—including resveratrol, garlic, curcumin, cinnamon, ginger, nuts, berberine, anthocyanins, soybeans, flaxseed, vegetable oils, and soluble fibers—on insulin resistance and glucose homeostasis in patients with type 2 diabetes. These compounds demonstrated beneficial effects by improving insulin sensitivity, reducing fasting blood sugar

Read More »
June 26, 2025 No Comments

Magnesium improves the beta-cell function to compensate variation of insulin sensitivity: double- blind, randomized clinical trial

This double-blind, randomized controlled trial assessed the impact of oral magnesium chloride (2.5 g/day) for three months on beta-cell function in 106 non-diabetic, normotensive adults with hypomagnesemia. The magnesium group showed a significant increase in the area under the curve (AUC) for the hyperbolic model of beta-cell function—from 7.591 to

Read More »
June 26, 2025 No Comments

Mitochondrial Dysfunction and Neurodegenerative Disorders: Role of Nutritional Supplementation

This systematic review examines the role of mitochondrial dysfunction in various neurodegenerative diseases—such as Parkinson’s disease, Alzheimer’s disease, ALS, multiple system atrophy, and progressive supranuclear palsy—and explores the potential benefits of nutritional supplementation with CoQ10, B-vitamins/NADH, L-carnitine, vitamin D, and alpha-lipoic acid. These nutrients are proposed to support mitochondrial ATP

Read More »
June 26, 2025 No Comments

Modulation of the hypothalamic-pituitary-adrenal (HPA) axis by plants and phytonutrients: a systematic review of human trials

This systematic review examined the effects of various plant-based compounds and phytonutrients—including ashwagandha, Rhodiola, St. John’s Wort, cannabidiol, and curcumin—on the hypothalamic-pituitary-adrenal (HPA) axis in human clinical trials. While most phytonutrients yielded inconclusive results due to differences in study design and dosage, ashwagandha consistently demonstrated a reduction in morning cortisol

Read More »
June 26, 2025 No Comments

Multi-target neuroprotective effects of herbal medicines for Alzheimer’s disease

This in vitro study examined the neuroprotective effects of seven traditional medicinal plants—Scutellaria baicalensis, Ginkgo biloba, Hypericum perforatum, Curcuma longa, Lavandula angustifolia, Trigonella foenum-graecum, and Rosmarinus officinalis—in the context of Alzheimer’s disease. Researchers evaluated antioxidant activity, enzyme inhibition related to neurodegeneration (notably GSK-3β), cytotoxicity in brain endothelial and motor neuron

Read More »
June 26, 2025 No Comments