Well Referenced

Category: Vitamins, Supplements & Antioxidants

Nutritional support for disease prevention and cellular health.

Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials

This systematic review and meta-analysis examined the effects of curcumin/turmeric supplementation on inflammatory and oxidative stress markers across 66 randomized controlled trials. The results showed significant reductions in C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6), along with improvements in total antioxidant capacity (TAC), superoxide dismutase (SOD) activity,

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June 26, 2025 No Comments

Homocysteine and markers of inflammation in acute coronary syndrome

This observational study examined the associations between elevated total homocysteine (tHcy) levels, inflammatory markers (HsCRP, IL-6, TNFα), and coronary artery disease (CAD) severity in acute coronary syndrome (ACS) patients. The researchers found higher levels of tHcy, HsCRP, and proinflammatory cytokines correlated with an increased number of diseased vessels, while folate

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June 26, 2025 No Comments

The association between homocysteine and myocardial infarction is independent of age, sex, blood pressure, cholesterol, smoking and markers of inflammation: the Glasgow Myocardial Infarction Study

This case-control study from the Glasgow Myocardial Infarction Study evaluated the association between plasma homocysteine levels and myocardial infarction (MI) in 712 MI patients and 697 age- and sex-matched controls. Results showed that elevated homocysteine levels were significantly associated with nearly double the risk of MI (OR 1.9; 95% CI:

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June 26, 2025 No Comments

The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging

This observational study examined the relationship between anti-inflammatory diet components, physical activity, and markers of chronic low-grade inflammation (“inflammaging”) in 60 Polish adults aged 65 and older. Participants with lower levels of inflammation (LGI group) had higher intake of vitamin D, a more favorable n-6/n-3 PUFA ratio, and better physical

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June 26, 2025 No Comments

Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy

The study “Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy,” published in Nature Medicine (2003), investigated benfotiamine, a lipid-soluble form of thiamine (vitamin B1), and its ability to prevent diabetic retinopathy by simultaneously inhibiting three harmful metabolic pathways activated by high blood sugar—the hexosamine, DAG-PKC,

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June 26, 2025 No Comments

Supplementation of Lipoic Acid, Zinc and Clopidogrel Reduces Mortality Rate and Incidence of Ventricular Arrhythmia in Experimental Myocardial Infarction

This 2021 animal study published in Frontiers in Physiology (DOI: 10.3389/fphys.2021.582223, PMCID: PMC8009994) evaluated the cardioprotective effects of lipoic acid, zinc, and clopidogrel in Wistar rats with isoproterenol-induced myocardial infarction (MI). The study found that pre-treatment with these agents reduced mortality rates, ventricular arrhythmias, ST-segment elevation, and CK-MB levels. Lipoic

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June 26, 2025 No Comments

Management of the aging risk factor for Parkinson’s disease

This 2014 review published in Neurobiology of Aging (DOI: 10.1016/j.neurobiolaging.2013.10.073, PMID: 24246717) explores how aging—a primary risk factor for Parkinson’s disease (PD)—can be managed through targeted nutritional compounds, including alpha-lipoic acid, acetyl-L-carnitine, coenzyme Q10, and melatonin. These agents support mitochondrial energy metabolism, enhance antioxidant defenses, and modulate gene expression via

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June 26, 2025 No Comments

The beneficial effect of Alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines

This 2022 randomized, double-blind, placebo-controlled trial published in Scientific Reports (DOI: 10.1038/s41598-021-04397-z, PMID: 34997178) evaluated the effects of alpha-lipoic acid (ALA) supplementation in 92 women with episodic migraines. Over 3 months, participants receiving 300 mg/day of ALA experienced significant reductions in headache frequency, severity, and duration, along with decreased levels

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June 26, 2025 No Comments

Safety and efficacy of alpha-lipoic acid oral supplementation in the reduction of pain with unknown etiology: A monocentric, randomized, double-blind, placebo-controlled clinical trial

This 2021 monocentric, randomized, double-blind, placebo-controlled clinical trial published in Biomedicine & Pharmacotherapy (DOI: 10.1016/j.biopha.2021.112308, PMID: 34649217) evaluated the safety and efficacy of alpha-lipoic acid (ALA) supplementation for reducing chronic pain of unknown etiology. Involving 100 adult participants over 60 days, the study found that ALA significantly reduced pain intensity

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June 26, 2025 No Comments

Effects of alpha-lipoic Acid on body weight in obese subjects

This 2011 randomized, double-blind, placebo-controlled trial published in The American Journal of Medicine (DOI: 10.1016/j.amjmed.2010.08.005, PMID: 21187189) evaluated the effects of alpha-lipoic acid (ALA) supplementation on body weight in 360 obese adults over 20 weeks. Participants were assigned to receive either 1200 mg or 1800 mg of ALA daily, or

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June 26, 2025 No Comments