This retrospective nested case-control study analyzed data from 12,676 bariatric surgery patients in Quebec (2001–2014), matched with 38,028 obese and 126,760 non-obese controls. Over a mean follow-up of 4.4 years, bariatric patients exhibited a higher postoperative fracture risk compared to obese (RR 1.38; 95% CI: 1.23–1.55) and non-obese controls (RR
This retrospective cohort study analyzed Medicare claims data from 42,345 severely obese adults (29,624 underwent Roux-en-Y gastric bypass [RYGB]; 12,721 underwent adjustable gastric banding [AGB]) between 2006 and 2014. Over a mean follow-up of 3.5 years, RYGB was associated with a 73% higher risk of nonvertebral fractures compared to AGB
This randomized controlled trial evaluated the effects of weight loss, with or without exercise, on serum sclerostin levels and hip geometry in 107 obese adults aged ≥65 years. Participants were assigned to one of four groups: control, diet-induced weight loss, exercise, or combined diet-exercise, over 12 months. The diet group
This 2010 review explores the role of progesterone in bone health, emphasizing its contribution to bone formation and maintenance in women. Progesterone stimulates osteoblast differentiation and, alongside estrogen, helps regulate bone remodeling. The article highlights that cyclic progestin therapy can prevent bone loss in premenopausal women with amenorrhea or subclinical
This 2012 cohort study published in Magnesium Research analyzed data from 4,107 U.S. adults in the NHANES 2001–2006 dataset to examine the relationship between magnesium intake and serum vitamin D levels. The findings showed that higher magnesium intake was significantly associated with increased serum 25(OH)D levels and a lower risk
The review titled “DHEA in bone: the role in osteoporosis and fracture healing” (Archives of Osteoporosis, 2020, PMID: 32504237) examines the role of dehydroepiandrosterone (DHEA) in improving bone mineral density and potentially facilitating fracture healing. It highlights DHEA’s anabolic action on bone through stimulating osteoblast activity and increasing insulin-like growth
The review article titled “DHEA in bone: the role in osteoporosis and fracture healing” (Archives of Osteoporosis, 2020, PMID: 32504237) explores the potential role of dehydroepiandrosterone (DHEA) in improving bone health, particularly its effects on osteoporosis and fracture healing. DHEA, a precursor to estrogen and testosterone, has been shown to
This study investigated the long-term benefits of short-term hormone replacement therapy (HRT) on bone health in postmenopausal women. A total of 347 healthy postmenopausal women participated in placebo-controlled trials, receiving either HRT or placebo for 2-3 years. Follow-up assessments conducted 5, 11, or 15 years after discontinuation showed that women
This study investigates the effects of sublingual testosterone (SLT) on muscle mass, strength, and bone turnover in hypogonadal men. After six months of treatment with 5 mg of SLT three times daily, participants showed significant increases in lean body mass, particularly in the legs, and improvements in muscle strength. Additionally,
This narrative review explores the role of testosterone in bone health, particularly in men with testosterone deficiency, osteopenia, or osteoporosis. The review highlights that testosterone is crucial for maintaining bone mineral density (BMD), and testosterone replacement therapy (TRT) has been shown to improve BMD in hypogonadal men. However, while TRT
