Well Referenced

Tag: PCOS

The Effects of Metformin or Orlistat on Obese Women with Polycystic Ovary Syndrome: A Prospective Randomized Open-Label Study

This 2011 prospective randomized open-label study compared the effects of metformin and orlistat on hormonal profiles, lipid parameters, and ovulation rates in 80 obese women with PCOS over a 3-month period. Both treatments led to significant reductions in body weight, BMI, and waist circumference, with no significant difference between the

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June 26, 2025 No Comments

The Role of Orlistat Combined with Lifestyle Changes in the Management of Overweight and Obese Patients with Polycystic Ovary Syndrome

This 2014 prospective study evaluated the effects of combining orlistat (120 mg three times daily) with lifestyle modifications (low-calorie diet and exercise) over six months in 101 women with PCOS and 29 BMI-matched controls. Both groups experienced significant BMI reductions. In the PCOS group, there were notable improvements in insulin

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June 26, 2025 No Comments

Short-term combined treatment with liraglutide and metformin leads to significant weight loss in obese women with polycystic ovary syndrome and previous poor response to metformin

This 12-week open-label, prospective study evaluated the efficacy of combining liraglutide (1.2 mg/day subcutaneously) with metformin (1000 mg twice daily) in 40 obese, non-diabetic women with PCOS who had previously lost less than 5% body weight on metformin monotherapy. Participants were randomized into three groups: metformin alone (MET), liraglutide alone

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June 26, 2025 No Comments

Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials

This 2023 systematic review and meta-analysis evaluated 26 randomized controlled trials involving 1,691 women with polycystic ovary syndrome (PCOS) to assess the efficacy and safety of inositol supplementation. Inositol significantly increased the likelihood of menstrual cycle normalization compared to placebo (risk ratio: 1.79; 95% CI: 1.13–2.85) and was non-inferior to

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June 26, 2025 No Comments

Comparison of metformin plus myoinositol vs metformin alone in PCOS women undergoing ovulation induction cycles: randomized controlled trial

This randomized controlled trial compared the effectiveness of Metformin plus Myoinositol versus Metformin alone in improving fertility outcomes for women with polycystic ovary syndrome (PCOS) undergoing ovulation induction. The study found that the combination of Metformin and Myoinositol significantly increased the live birth rate (55%) compared to Metformin alone (26.67%).

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June 26, 2025 No Comments

Comparison of myo-inositol and metformin on glycemic control, lipid profiles, and gene expression related to insulin and lipid metabolism in women with polycystic ovary syndrome: a randomized controlled clinical trial

This randomized controlled trial compared the effects of Myo-Inositol and Metformin on glycemic control, lipid profiles, and gene expression related to insulin and lipid metabolism in women with polycystic ovary syndrome (PCOS). The study found that both treatments improved insulin sensitivity and lipid metabolism, but Myo-Inositol showed superior results, particularly

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June 26, 2025 No Comments

Berberine Phospholipid Is an Effective Insulin Sensitizer and Improves Metabolic and Hormonal Disorders in Women with Polycystic Ovary Syndrome: A One-Group Pretest-Post-Test Explanatory Study

The study “Berberine Phospholipid Is an Effective Insulin Sensitizer and Improves Metabolic and Hormonal Disorders in Women with Polycystic Ovary Syndrome,” published in Nutrients (2021), investigated the effects of berberine phospholipid supplementation on insulin sensitivity and metabolic and hormonal disturbances in women with polycystic ovary syndrome (PCOS). The results indicated

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June 26, 2025 No Comments

Berberine, a Herbal Metabolite in the Metabolic Syndrome: The Risk Factors, Course, and Consequences of the Disease

This review article examines the pharmacological effects of berberine, a herbal metabolite, in managing metabolic syndrome and associated conditions like type 2 diabetes, obesity, atherosclerosis, cardiovascular diseases, and polycystic ovary syndrome (PCOS). Berberine improves insulin sensitivity, reduces blood glucose, lowers LDL cholesterol, mitigates inflammation by inhibiting COX-2, and induces apoptosis

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June 26, 2025 No Comments

The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients

This randomized controlled trial examined the effects of Coenzyme Q10 (CoQ10) supplementation on inflammatory and endothelial dysfunction markers in overweight and obese women with Polycystic Ovary Syndrome (PCOS). Over 8 weeks, CoQ10 significantly reduced levels of TNF-α, hs-CRP, IL-6, VCAM-1, and E-selectin, indicating improved inflammatory status and vascular function, although

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June 26, 2025 No Comments