This 2013 open-label pilot study titled "Ozone therapy as add-on treatment in fibromyalgia management by rectal insufflation" (Journal of Alternative and Complementary Medicine, DOI: [10.1089/acm.2011.0739]*) evaluated the effects of ozone therapy administered via rectal insufflation over 12 weeks in fibromyalgia patients. Participants showed significant improvements in Fibromyalgia Impact Questionnaire (FIQ)
