Well Referenced

Tag: pilot study

Treatment of Diabetic Impotence with Umbilical Cord Blood Stem Cell Intracavernosal Transplant: Preliminary Report of 7 Cases

This 2010 pilot study assessed the safety and efficacy of intracavernosal injections of human umbilical cord blood stem cells (hUCBSCs) in seven male patients (ages 57–87) with type 2 diabetes mellitus and refractory erectile dysfunction (ED). Each patient received a single injection of 1.5×10⁷ hUCBSCs without immunosuppression. Over a 9-month

Read More »
June 26, 2025 No Comments

Effects of Stem Cell Treatment in Human Patients With Peyronie Disease

This prospective pilot study evaluated the safety and efficacy of intracavernosal injections of placental matrix-derived mesenchymal stem cells (PM-MSCs) in five male patients aged 45–59 with Peyronie’s disease (PD). Patients received a single PM-MSC injection and were followed at 6 weeks, 3 months, and 6 months. Significant improvements were observed

Read More »
June 26, 2025 No Comments

Safety and Efficacy of Allogenic Placental Mesenchymal Stem Cells for Treating Knee Osteoarthritis: A Pilot Study

This double-blind, placebo-controlled pilot study evaluated the safety and efficacy of intra-articular injections of allogenic placental mesenchymal stem cells (MSCs) in 20 patients with symptomatic knee osteoarthritis (OA). Participants received either 0.5–0.6 × 10⁸ allogenic placenta-derived MSCs or saline placebo. Over 24 weeks, the MSC group demonstrated significant improvements in

Read More »
June 26, 2025 No Comments

Ozone therapy as add-on treatment in fibromyalgia management by rectal insufflation: an open-label pilot study

This 2013 open-label pilot study titled “Ozone therapy as add-on treatment in fibromyalgia management by rectal insufflation” (Journal of Alternative and Complementary Medicine, DOI: [10.1089/acm.2011.0739]*) evaluated the effects of ozone therapy administered via rectal insufflation over 12 weeks in fibromyalgia patients. Participants showed significant improvements in Fibromyalgia Impact Questionnaire (FIQ)

Read More »
June 26, 2025 No Comments

Reduction of fibromyalgia symptoms through intravenous nutrient therapy: results of a pilot clinical trial

This pilot clinical study evaluated the effects of intravenous nutrient therapy (modified Myers’ Cocktail) in seven patients with therapy-resistant fibromyalgia. Over eight weeks, participants received weekly infusions and reported significant reductions in pain (60%) and fatigue (80%) (p=0.005), along with noticeable improvements in energy and daily functioning within 24–48 hours

Read More »
June 26, 2025 No Comments

The Effects of Cold Exposure Training and a Breathing Exercise on the Inflammatory Response in Humans: A Pilot Study

This pilot study explored the effects of cold exposure training combined with a specific breathing exercise on the inflammatory response in healthy males. The intervention increased plasma epinephrine levels and significantly attenuated the LPS-induced inflammatory response, highlighting its potential to modulate immune responses. While the study showed promise, its small

Read More »
June 26, 2025 No Comments

Liver-Oriented Acute Metabolic Effects of A Low Dose of L-Carnitine under Fat-Mobilizing Conditions: Pilot Human Clinical Trial

This randomized controlled pilot study examined the acute metabolic effects of a low dose (500 mg) of L-carnitine on hepatic fatty acid oxidation and glucose metabolism under fat-mobilizing conditions in healthy adults. Following a 12-hour fast and a 60-minute lipid and heparin infusion to stimulate fat mobilization, participants receiving L-carnitine

Read More »
June 26, 2025 No Comments