This 2016 animal study assessed the impact of preoperative rectal ozone insufflation on surgical wound healing in rabbits. Twenty-one rabbits were divided into three groups: sham, surgical wound without treatment, and surgical wound with ozone therapy (70 µg/mL O₂-O₃ mixture, 12 mL, administered rectally every other day for six sessions).
This 2021 review by Viebahn-Haensler and León Fernández explores the therapeutic potential of low-dose ozone therapy in managing chronic inflammatory diseases characterized by oxidative stress and immune dysregulation. The authors describe how ozone, administered in controlled low doses, acts as a bioregulator by forming “ozone peroxides” that mimic hydrogen peroxide’s
This 2012 review by Bocci et al. discusses the clinical applications and safety considerations of oxygen-ozone therapy (OOT), particularly focusing on ozonated saline infusion and rectal insufflation. While intradiscal ozone injections have shown success in treating herniated discs, systemic applications like ozonated saline and rectal insufflation lack standardization and may
This 2021 study evaluated the long-term efficacy of adjuvant ozone therapy (O₃T) in managing chronic pelvic pain in cancer survivors. Six patients with refractory pelvic pain, unresponsive to standard treatments, received O₃T via rectal insufflation. Pain levels, assessed using the Visual Analog Scale (VAS), showed significant reductions: continuous pelvic pain
This 2013 open-label pilot study titled “Ozone therapy as add-on treatment in fibromyalgia management by rectal insufflation” (Journal of Alternative and Complementary Medicine, DOI: [10.1089/acm.2011.0739]*) evaluated the effects of ozone therapy administered via rectal insufflation over 12 weeks in fibromyalgia patients. Participants showed significant improvements in Fibromyalgia Impact Questionnaire (FIQ)
