Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy

This 1995 preclinical study investigated the therapeutic potential of lipoic acid (LA) in a streptozotocin-induced rat model of diabetic neuropathy. LA was administered intraperitoneally at doses of 20, 50, and 100 mg/kg, five times per week. The treatment significantly enhanced nerve blood flow, restored reduced glutathione levels, and improved distal