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Tag: diabetic neuropathy

Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy

This 1995 preclinical study investigated the therapeutic potential of lipoic acid (LA) in a streptozotocin-induced rat model of diabetic neuropathy. LA was administered intraperitoneally at doses of 20, 50, and 100 mg/kg, five times per week. The treatment significantly enhanced nerve blood flow, restored reduced glutathione levels, and improved distal

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June 26, 2025 No Comments

Novel Actions of Progesterone: What We Know Today and What Will Be the Scenario in the Future?

This 2012 review highlights emerging non-reproductive roles of progesterone, including potential therapeutic applications in traumatic brain injury (TBI), stroke, Alzheimer’s disease, diabetic neuropathy, and crush injuries. Preclinical and early clinical studies suggest that progesterone and its derivatives, such as norethisterone and megestrol acetate, may offer neuroprotective and anti-inflammatory benefits. Additionally,

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June 26, 2025 No Comments

The multifaceted therapeutic potential of benfotiamine

This article discusses the therapeutic effects of benfotiamine, a synthetic derivative of thiamine (vitamin B1), in reducing advanced glycation end products (AGEs), which contribute to complications like diabetic neuropathy, nephropathy, and retinopathy. Benfotiamine enhances transketolase activity, thus reducing AGE accumulation and preventing these complications. In addition to its AGE-related effects,

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June 26, 2025 No Comments

Long term magnesium supplementation influences favourably the natural evolution of neuropathy in Mg-depleted type 1 diabetic patients (T1dm)

This clinical trial examined the effects of long-term magnesium supplementation on the progression of diabetic neuropathy in magnesium-deficient patients with type 1 diabetes mellitus (T1DM). The study found that sustained magnesium intake favorably influenced the natural evolution of neuropathy, suggesting therapeutic potential for magnesium in managing nerve-related complications of diabetes.

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June 26, 2025 No Comments

Alpha-Lipoic Acid and Diabetic Neuropathy

This review article explores the role of alpha-lipoic acid (ALA) in managing diabetic peripheral neuropathy, highlighting its antioxidant properties and therapeutic potential. ALA reduces oxidative stress, enhances reduced glutathione levels, and protects nerves from hyperglycemia-induced damage. Clinical trials have demonstrated that 600 mg of ALA daily, administered either intravenously or

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June 26, 2025 No Comments