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Tag: preclinical study

Comparison efficacy of ESWT and Wharton’s jelly mesenchymal stem cell in early osteoarthritis of rat knee

This 2019 preclinical study evaluated the therapeutic effects of extracorporeal shockwave therapy (ESWT), Wharton’s jelly-derived mesenchymal stem cells (WJMSCs), and their combination in a rat model of early knee osteoarthritis (KOA). All treatment modalities significantly improved cartilage integrity and subchondral bone remodeling, as evidenced by pathological assessments, micro-CT, and immunohistochemical

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June 26, 2025 No Comments

Effects of convection-enhanced delivery of bevacizumab on survival of glioma-bearing animals

This preclinical study evaluated the efficacy of convection-enhanced delivery (CED) of bevacizumab, alone or combined with irinotecan, in murine models bearing intracranial gliomas (U87 and U251 cell lines). CED-treated mice demonstrated a 30% longer survival compared to those receiving intravenous (IV) bevacizumab. The combination of CED bevacizumab and intraperitoneal irinotecan

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June 26, 2025 No Comments

The Opioid Antagonist Naltrexone Improves Murine Inflammatory Bowel Disease

This 2008 preclinical study investigated the effects of naltrexone, an opioid receptor antagonist, on inflammatory bowel disease (IBD) in murine models. The findings demonstrated that naltrexone administration led to significant improvements in colitis symptoms, including reduced inflammation and mucosal damage. The proposed mechanism involves modulation of the immune response through

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June 26, 2025 No Comments

Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy

This 1995 preclinical study investigated the therapeutic potential of lipoic acid (LA) in a streptozotocin-induced rat model of diabetic neuropathy. LA was administered intraperitoneally at doses of 20, 50, and 100 mg/kg, five times per week. The treatment significantly enhanced nerve blood flow, restored reduced glutathione levels, and improved distal

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June 26, 2025 No Comments

Responses of Melanoma Cells to Photobiomodulation Depend on Cell Pigmentation and Light Parameters

This 2022 preclinical study investigated the effects of photobiomodulation (PBM) on melanoma cells with varying pigmentation levels. The researchers found that near-infrared (NIR) irradiation at 30 J/cm² increased invasiveness in pigmented melanoma cells, whereas all light doses inhibited cell migration. Conversely, a high dose (150 J/cm²) of red laser light

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June 26, 2025 No Comments

Supplementation of Lipoic Acid, Zinc and Clopidogrel Reduces Mortality Rate and Incidence of Ventricular Arrhythmia in Experimental Myocardial Infarction

This 2021 animal study published in Frontiers in Physiology (DOI: 10.3389/fphys.2021.582223, PMCID: PMC8009994) evaluated the cardioprotective effects of lipoic acid, zinc, and clopidogrel in Wistar rats with isoproterenol-induced myocardial infarction (MI). The study found that pre-treatment with these agents reduced mortality rates, ventricular arrhythmias, ST-segment elevation, and CK-MB levels. Lipoic

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June 26, 2025 No Comments

Preclinical effects of melanocortins in male sexual dysfunction

This preclinical study examines the effects of melanocortins, particularly bremelanotide, on male sexual dysfunction, specifically focusing on its ability to promote erections and enhance sexual activity behaviors. The results suggest that bremelanotide, a melanocortin receptor agonist, may offer a promising treatment for sexual dysfunction by interacting with the central nervous

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June 26, 2025 No Comments

Bremelanotide: an overview of preclinical CNS effects on female sexual function

This preclinical study examined the effects of bremelanotide, an α-MSH analogue, on sexual desire in female rats, focusing on its impact on specific brain regions. Results showed that bremelanotide significantly increased solicitation behaviors, an indicator of heightened sexual desire, without affecting pacing or lordosis. These effects were linked to activation

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June 26, 2025 No Comments