Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan

This 2020 review discusses the role of the kynurenine pathway in converting tryptophan to NAD+, a crucial cofactor in mitochondrial energy production and redox reactions. Age-related decline in NAD+ levels is linked to metabolic and neurodegenerative diseases. The review highlights how interventions targeting the kynurenine pathway can extend lifespan in