Well Referenced

Tag: Mitochondrial Dynamics

Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan

This 2020 review discusses the role of the kynurenine pathway in converting tryptophan to NAD+, a crucial cofactor in mitochondrial energy production and redox reactions. Age-related decline in NAD+ levels is linked to metabolic and neurodegenerative diseases. The review highlights how interventions targeting the kynurenine pathway can extend lifespan in

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June 26, 2025 No Comments

Sulforaphane – role in aging and neurodegeneration

This 2019 review explores sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables, highlighting its potential in mitigating aging and neurodegenerative processes. SFN activates the Nrf2 pathway, enhancing antioxidant responses, and inhibits NF-κB, reducing inflammation. It also exhibits epigenetic effects by inhibiting histone deacetylases and DNA methyltransferases, and modulates mitochondrial dynamics.

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June 26, 2025 No Comments