Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons: An Evidence Review for the U.S. Preventive Services Task Force

This 2022 systematic review evaluated the benefits and harms of systemic hormone therapy (HT) for the primary prevention of chronic conditions in postmenopausal individuals. Analyzing 20 trials (n=39,145) and 3 cohort studies (n=1,155,410), the review found that while HT reduced risks of diabetes and fractures, it increased risks of gallbladder