Well Referenced

Tag: systematic review

The efficacy and safety of extracorporeal shockwave therapy in knee osteoarthritis: A systematic review and meta-analysis

This 2020 systematic review and meta-analysis evaluated the efficacy and safety of extracorporeal shockwave therapy (ESWT) in treating knee osteoarthritis (KOA). Analyzing three randomized controlled trials and three cohort studies encompassing 589 patients, the study found that ESWT significantly reduced pain scores at 4, 8, and 12 weeks post-treatment, with

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June 26, 2025 No Comments

Serious Adverse Events of Cell Therapy for Respiratory Diseases: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis assessed the safety profile of cell-based therapies in respiratory diseases by analyzing 23 clinical studies involving 204 patients with conditions such as ARDS, COPD, IPF, PAH, and others. The findings indicated that both systemic infusions and bronchial instillations of mesenchymal stem/stromal or progenitor cells were

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June 26, 2025 No Comments

Concise Review: Stem Cell Interventions for People With Cerebral Palsy: Systematic Review With Meta-Analysis

This systematic review and meta-analysis evaluated the efficacy and safety of stem cell therapies in individuals with cerebral palsy (CP). Analyzing five clinical trials encompassing 328 participants, the study examined various stem cell types, including olfactory ensheathing cells, neural stem cells, neural progenitors, and allogeneic umbilical cord blood cells. The

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June 26, 2025 No Comments

Safety and Efficacy of Adult Stem Cell Therapy for Acute Myocardial Infarction and Ischemic Heart Failure (SafeCell Heart): A Systematic Review and Meta-Analysis

This systematic review and meta-analysis evaluated the safety and efficacy of mesenchymal stem cell (MSC) therapy in adults with acute myocardial infarction (AMI) and ischemic heart failure (IHF). Analyzing 23 clinical trials (11 on AMI and 12 on IHF), the study found that MSC therapy was not associated with acute

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June 26, 2025 No Comments

Metformin for Weight Reduction in Non-Diabetic Patients on Antipsychotic Drugs: A Systematic Review and Meta-Analysis

This 2011 systematic review and meta-analysis evaluated the efficacy of metformin in mitigating weight gain induced by atypical antipsychotics in non-diabetic patients. Analyzing seven randomized, placebo-controlled trials encompassing 398 participants (five studies in adults and two in children), the study found that metformin significantly reduced body weight compared to placebo.

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June 26, 2025 No Comments

Effects of Weight-Loss Medications on Cardiometabolic Risk Profiles: A Systematic Review and Network Meta-analysis

This 2018 systematic review and network meta-analysis evaluated the impact of FDA-approved weight-loss medications—phentermine-topiramate, liraglutide, naltrexone-bupropion, lorcaserin, and orlistat—on cardiometabolic risk factors in obese adults. Analyzing 28 randomized controlled trials encompassing 29,018 participants, the study found that these medications led to modest reductions in fasting blood glucose (mean decrease of

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June 26, 2025 No Comments

A Systematic Review of Dextrose Prolotherapy for Chronic Musculoskeletal Pain

This 2016 systematic review by Hauser et al. analyzed 33 studies, including 15 RCTs, to evaluate the efficacy of dextrose prolotherapy in treating chronic musculoskeletal pain. The review found that dextrose prolotherapy is supported for managing tendinopathies, knee and finger joint osteoarthritis, and spinal/pelvic pain due to ligament dysfunction. Most

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June 26, 2025 No Comments

Oxygen-Ozone Therapy for the Treatment of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials

This 2020 systematic review analyzed 11 randomized controlled trials involving 858 patients to assess the efficacy and safety of intra-articular oxygen-ozone therapy (OOT) for knee osteoarthritis (KOA). The studies compared OOT with various treatments, including placebo, hyaluronic acid, corticosteroids, platelet-rich plasma, hypertonic dextrose, radiofrequency, and celecoxib plus glucosamine. While OOT

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June 26, 2025 No Comments

Ozone Therapy in Knee Osteoarthritis: A Systematic Review

This 2018 systematic review analyzed six randomized controlled trials assessing the efficacy of ozone therapy in knee osteoarthritis (KOA). The studies primarily involved elderly patients with mild to moderate KOA. Findings indicated that ozone therapy provided short-term pain relief, particularly when combined with hyaluronic acid, but was not superior to

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June 26, 2025 No Comments