This 2021 narrative review emphasizes the critical role of early and sustained nutritional interventions in promoting healthy aging. It highlights that adherence to nutrient-dense, plant-based diets with low glycemic loads can prevent or mitigate age-related conditions such as sarcopenia, cognitive decline, osteoporosis, and chronic diseases. The review underscores the importance
This 2022 systematic review evaluated the benefits and harms of systemic hormone therapy (HT) for the primary prevention of chronic conditions in postmenopausal individuals. Analyzing 20 trials (n=39,145) and 3 cohort studies (n=1,155,410), the review found that while HT reduced risks of diabetes and fractures, it increased risks of gallbladder
This 2022 recommendation from the US Preventive Services Task Force (USPSTF) advises against the use of hormone therapy—either combined estrogen and progestin or estrogen alone—for the primary prevention of chronic conditions such as cardiovascular disease, osteoporosis, and cancer in asymptomatic postmenopausal individuals. The USPSTF assigns a Grade D recommendation, indicating
This 2015 observational study published in Nutrition Research analyzed data from 9,148 U.S. adults aged 40 and older using NHANES 2005–2010 to examine the relationship between dietary magnesium intake, C-reactive protein (CRP), and the prevalence of metabolic syndrome (MetS). The study found that individuals in the highest quintile of magnesium
This 2015 prospective cohort study from the Japan Collaborative Cohort (JACC) study, published in the Journal of Clinical Nutrition, followed 58,615 adults aged 40–79 over a median of 14.7 years to examine the impact of dietary magnesium intake on mortality outcomes. Participants in the highest quintile of magnesium intake had
This review explores the MTHFR C677T polymorphism, a genetic variation that affects folate metabolism and leads to elevated homocysteine levels, which are associated with an increased risk of cardiovascular diseases, neurological disorders, diabetes, and other health conditions. The article discusses the need for genetic testing and the use of folic
This narrative review discusses the powerful antioxidant properties of dietary polyphenols, found in foods like fruits, vegetables, and beverages such as tea and wine. The review highlights how these compounds help mitigate oxidative stress, which is a contributor to chronic diseases such as neurodegenerative disorders, cardiovascular diseases, cancer, diabetes, and
This editorial discusses the health benefits of polyphenol-rich foods, which are associated with a reduced risk of chronic diseases such as cardiovascular diseases, certain cancers, and neurodegenerative disorders. Polyphenols, known for their antioxidant and chemopreventive properties, exert protective effects through antioxidant activities and modulation of cellular pathways involved in inflammation
This systematic review explores the health benefits of polyphenols, which are abundant in foods like fruits, vegetables, tea, and coffee. Polyphenols have demonstrated antioxidant properties and have been shown to prevent and manage chronic diseases such as obesity, atherosclerosis, diabetes, hypertension, cancer, and neurological disorders. The review discusses the mechanisms
This systematic review highlights the essential role of magnesium in over 300 enzymatic reactions and its broad therapeutic potential across various health domains. Magnesium deficiency is linked to numerous chronic diseases including Alzheimer’s, insulin resistance, type 2 diabetes, hypertension, cardiovascular conditions, migraines, and ADHD. The review underscores magnesium’s physiological importance
