Effects of oral versus transdermal menopausal hormone treatments on self-reported sleep domains and their association with vasomotor symptoms in recently menopausal women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS)

This randomized controlled trial, published in Menopause in 2018 (PMID: 28832429), examined the effects of oral conjugated equine estrogens (o-CEE) and transdermal estradiol (t-E2) on sleep quality in recently menopausal women as part of the Kronos Early Estrogen Prevention Study (KEEPS). Both hormone treatments significantly improved global Pittsburgh Sleep Quality