Well Referenced

Tag: sleep disturbances

Inflammation and behavioral symptoms after breast cancer treatment: do fatigue, depression, and sleep disturbance share a common underlying mechanism?

This observational study examined 103 women who recently completed early-stage breast cancer treatment, finding that over 60% experienced fatigue and sleep disturbances, and 25% showed elevated depressive symptoms. Chemotherapy was associated with higher levels of fatigue, sleep problems, depressive symptoms, and increased levels of the inflammatory marker sTNF-RII (all P

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June 26, 2025 No Comments

Progesterone prevents sleep disturbances and modulates GH, TSH, and melatonin secretion in postmenopausal women

This randomized, double-blind, placebo-controlled study evaluated the effects of 300 mg of oral progesterone administered nightly for three weeks on sleep architecture and hormonal profiles in healthy postmenopausal women. The results indicated that while progesterone did not affect undisturbed sleep, it significantly improved sleep disturbances caused by blood sampling, reducing

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June 26, 2025 No Comments

Effects of oral versus transdermal menopausal hormone treatments on self-reported sleep domains and their association with vasomotor symptoms in recently menopausal women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS)

This randomized controlled trial, published in Menopause in 2018 (PMID: 28832429), examined the effects of oral conjugated equine estrogens (o-CEE) and transdermal estradiol (t-E2) on sleep quality in recently menopausal women as part of the Kronos Early Estrogen Prevention Study (KEEPS). Both hormone treatments significantly improved global Pittsburgh Sleep Quality

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June 26, 2025 No Comments

Efficacy of Micronized Progesterone for Sleep: A Systematic Review and Meta-analysis of Randomized Controlled Trial Data

A 2021 systematic review and meta-analysis published in the Journal of Clinical Endocrinology & Metabolism (PMID: 33245776) assessed the impact of micronized progesterone on sleep outcomes, particularly in postmenopausal women. The study analyzed nine randomized controlled trials with a total of 388 participants. Results indicated that micronized progesterone improved sleep

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June 26, 2025 No Comments