This article highlights the benefits and safety of hormone replacement therapy (HRT) for women, particularly those starting before the age of 60. It reviews how HRT alleviates symptoms of estrogen deficiency such as hot flashes, vaginal dryness, and osteoporotic fractures, with transdermal estradiol being preferred for its safety. HRT also
This randomized controlled trial, published in Menopause in 2018 (PMID: 28832429), examined the effects of oral conjugated equine estrogens (o-CEE) and transdermal estradiol (t-E2) on sleep quality in recently menopausal women as part of the Kronos Early Estrogen Prevention Study (KEEPS). Both hormone treatments significantly improved global Pittsburgh Sleep Quality
This review critically examines the growing popularity of custom-compounded bioidentical hormone therapy (CBHT) and highlights significant safety concerns, including severe adverse events from compounding errors, such as deaths from contaminated products and cases of end-stage renal failure. Oral estrogens, particularly in excessive doses, are linked to an increased risk of
