Chronic Oxytocin Administration Inhibits Food Intake, Increases Energy Expenditure, and Produces Weight Loss in Fructose-Fed Obese Rhesus Monkeys

This 2015 study investigated the effects of chronic oxytocin (OT) administration on weight loss in diet-induced obese (DIO) male rhesus monkeys. Over a 4-week period, monkeys received subcutaneous OT injections at escalating doses (0.2 mg/kg for 2 weeks, then 0.4 mg/kg for 2 weeks). Results showed a significant reduction in