This review article explores the role of histamine as a central neurotransmitter in regulating appetite and metabolism. Histamine exerts anorexigenic effects primarily through H₁ receptor stimulation, mediating leptin’s inhibitory impact on appetite and potentially delaying leptin resistance in high-fat diet-induced obesity. Additionally, histamine may enhance lipolysis, contributing to weight regulation.
This 2015 study investigated the effects of chronic oxytocin (OT) administration on weight loss in diet-induced obese (DIO) male rhesus monkeys. Over a 4-week period, monkeys received subcutaneous OT injections at escalating doses (0.2 mg/kg for 2 weeks, then 0.4 mg/kg for 2 weeks). Results showed a significant reduction in
This review article examines the role of resveratrol, a polyphenolic compound found in red wine and certain plants, in promoting fat mobilization and combating obesity. Animal studies indicate that resveratrol supplementation leads to increased lipolysis, enhanced fatty acid oxidation, and reduced adipogenesis. Mechanistically, resveratrol activates SIRT1 and AMPK pathways, resulting
This 2008 review article explores the role of various dietary phytochemicals in modulating different stages of the adipocyte life cycle, including preadipocyte proliferation, differentiation (adipogenesis), lipid accumulation, and apoptosis. Compounds such as genistein, conjugated linoleic acid (CLA), docosahexaenoic acid (DHA), epigallocatechin gallate (EGCG), quercetin, resveratrol, and ajoene have been shown
This double-blind, placebo-controlled study evaluated the effects of daily consumption of a thermogenic drink (TD) over 28 days in 60 healthy adults (30 males, 30 females; mean age 23 years). Participants consumed 336 ml/day of either TD or a non-caffeinated placebo. After 28 days, the TD group exhibited significant reductions
This 2018 study investigated the role of cannabinoid type 1 receptors (CB1Rs) in brown adipose tissue (BAT) activation in humans and rodents. Using positron emission tomography (PET) imaging with the radioligand [^18F]FMPEP-d_2, researchers observed that cold exposure significantly increased CB1R density and glucose uptake in the BAT of lean men.
