oxytocin Archives - Well Referenced

Oxytocin’s Inhibitory Effect on Food Intake is Stronger in Obese than Normal-Weight Men

This 2016 double-blind, placebo-controlled study investigated the effects of intranasal oxytocin (24 IU) on food intake and metabolic parameters in 18 obese and 20 normal-weight men. Oxytocin significantly reduced hunger-driven food intake in the fasted state among obese participants but not in normal-weight individuals. Additionally, oxytocin decreased snack consumption in

June 26, 2025 No Comments

A New Horizon: Oxytocin as a Novel Therapeutic Option for Obesity and Diabetes

This 2013 review explores oxytocin (OXT) as a potential therapeutic agent for obesity and diabetes. Traditionally recognized for its role in reproduction, OXT has been found to influence metabolic regulation by acting on the hypothalamus to suppress appetite and increase energy expenditure. Animal studies demonstrate that OXT administration leads to

June 26, 2025 No Comments

Chronic Oxytocin Administration Inhibits Food Intake, Increases Energy Expenditure, and Produces Weight Loss in Fructose-Fed Obese Rhesus Monkeys

This 2015 study investigated the effects of chronic oxytocin (OT) administration on weight loss in diet-induced obese (DIO) male rhesus monkeys. Over a 4-week period, monkeys received subcutaneous OT injections at escalating doses (0.2 mg/kg for 2 weeks, then 0.4 mg/kg for 2 weeks). Results showed a significant reduction in

June 26, 2025 No Comments

Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models

This 2013 study evaluated the effects of oxytocin (OXT) and its analogs on obesity and diabetes. In a randomized pilot clinical trial, obese patients received intranasal OXT for 8 weeks, resulting in significant weight loss and reversal of prediabetic changes. In mouse models, both central and peripheral administration of OXT

June 26, 2025 No Comments

Oxytocin reduces caloric intake in men

This 2015 randomized, double-blind, placebo-controlled crossover study investigated the effects of a single intranasal dose of oxytocin (24 IU) on caloric intake and metabolic parameters in 25 healthy fasting men. Participants received either oxytocin or placebo before selecting and consuming a breakfast meal. Results demonstrated that oxytocin administration led to

June 26, 2025 No Comments

Oxytocin Reduces Reward-Driven Food Intake in Humans

This 2013 randomized, placebo-controlled crossover study investigated the effects of intranasal oxytocin (24 IU) on food intake and metabolic parameters in healthy men. Participants received oxytocin or placebo, and their food intake was assessed in both fasted and postprandial states. The study found that oxytocin administration significantly reduced snack consumption,

June 26, 2025 No Comments

Erectile Dysfunction: Treatments, Advances and New Therapeutic Strategies

This 2023 review outlines current and emerging treatments for erectile dysfunction (ED), affecting approximately 40% of men aged 40–70. First-line therapies include oral phosphodiesterase type 5 inhibitors (PDE5i) such as sildenafil and tadalafil, and intracavernosal injections of agents like prostaglandin E1. Experimental pharmacotherapies under investigation include dopamine D₄ receptor agonists,

June 26, 2025 No Comments

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