Well Referenced

Tag: energy expenditure

Oxytocin’s Inhibitory Effect on Food Intake is Stronger in Obese than Normal-Weight Men

This 2016 double-blind, placebo-controlled study investigated the effects of intranasal oxytocin (24 IU) on food intake and metabolic parameters in 18 obese and 20 normal-weight men. Oxytocin significantly reduced hunger-driven food intake in the fasted state among obese participants but not in normal-weight individuals. Additionally, oxytocin decreased snack consumption in

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June 26, 2025 No Comments

A New Horizon: Oxytocin as a Novel Therapeutic Option for Obesity and Diabetes

This 2013 review explores oxytocin (OXT) as a potential therapeutic agent for obesity and diabetes. Traditionally recognized for its role in reproduction, OXT has been found to influence metabolic regulation by acting on the hypothalamus to suppress appetite and increase energy expenditure. Animal studies demonstrate that OXT administration leads to

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June 26, 2025 No Comments

Chronic Oxytocin Administration Inhibits Food Intake, Increases Energy Expenditure, and Produces Weight Loss in Fructose-Fed Obese Rhesus Monkeys

This 2015 study investigated the effects of chronic oxytocin (OT) administration on weight loss in diet-induced obese (DIO) male rhesus monkeys. Over a 4-week period, monkeys received subcutaneous OT injections at escalating doses (0.2 mg/kg for 2 weeks, then 0.4 mg/kg for 2 weeks). Results showed a significant reduction in

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June 26, 2025 No Comments

Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction

This 2017 preclinical study investigated the long-term effects of activating the central melanocortin system via intracerebroventricular infusion of melanotan II (MTII), a potent melanocortin receptor agonist, in adult F344BN rats. Over a 40-day period, MTII administration led to a persistent reduction in body mass and adiposity, despite food intake returning

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June 26, 2025 No Comments

Comparison of weight loss induced by daily caloric restriction versus intermittent fasting (DRIFT) in individuals with obesity: study protocol for a 52-week randomized clinical trial

The DRIFT study is a 52-week randomized clinical trial designed to compare the effectiveness of daily caloric restriction (DCR) and intermittent fasting (IMF) in promoting weight loss among individuals with obesity. Participants are randomized into two groups: one following DCR and the other following IMF, with both groups receiving equivalent

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June 26, 2025 No Comments

The Role of Insufficient Sleep and Circadian Misalignment in Obesity

This 2022 review in Nature Reviews Endocrinology examines how insufficient sleep and circadian misalignment contribute to obesity and metabolic disorders. It highlights that insufficient sleep and circadian misalignment predispose individuals to poor metabolic health and promote weight gain. The review discusses the impact of insufficient sleep and circadian misalignment in

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June 26, 2025 No Comments

Metabolic sequelae of β-blocker therapy: weighing in on the obesity epidemic?

This 2011 study by Lee et al. investigates the metabolic effects of chronic β-blocker therapy. The research comprises a mechanistic study comparing energy expenditure (EE), diet-induced thermogenesis, and habitual activity between β-blocker-treated individuals and matched controls, alongside cross-sectional analyses of body weight, BMI, and waist circumference in patients from diabetes

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June 26, 2025 No Comments

The Effects of Thyroid Hormones on Brown Adipose Tissue in Humans: A PET-CT Study

This 2014 clinical investigation explored how thyroid hormones influence brown adipose tissue (BAT) activity in euthyroid human subjects using PET-CT imaging. Participants with higher circulating thyroid hormone levels, especially triiodothyronine (T3), demonstrated significantly increased glucose uptake in BAT, indicating heightened thermogenic activity. The study confirmed that thyroid hormones directly stimulate

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June 26, 2025 No Comments

Effect of Iodothyronines on Thermogenesis: Focus on Brown Adipose Tissue

This review examines the role of iodothyronines, particularly triiodothyronine (T3) and 3,5-diiodothyronine (3,5-T2), in regulating thermogenesis via brown adipose tissue (BAT). T3 enhances BAT thermogenic activity by upregulating uncoupling protein 1 (UCP1) expression and increasing mitochondrial biogenesis. 3,5-T2, a thyroid hormone metabolite, also stimulates BAT thermogenesis through mechanisms that are

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June 26, 2025 No Comments