This study elucidates a novel mechanism by which the DNA repair enzyme 8-oxoguanine DNA glycosylase-1 (OGG1) contributes to innate inflammation. Upon repairing oxidatively damaged DNA (specifically 8-oxoG lesions), OGG1 forms a complex with the excised base, acquiring guanine nucleotide exchange factor activity that activates KRAS. Activated KRAS then triggers downstream
