Innate Inflammation Induced by the 8-Oxoguanine DNA Glycosylase-1–KRAS–NF-κB Pathway
This study elucidates a novel mechanism by which the DNA repair enzyme 8-oxoguanine DNA glycosylase-1 (OGG1) contributes to innate inflammation. Upon repairing oxidatively damaged DNA (specifically 8-oxoG lesions), OGG1 forms a complex with the excised base, acquiring guanine nucleotide exchange factor activity that activates KRAS. Activated KRAS then triggers downstream
June 26, 2025
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