Well Referenced

Tag: chemokines

Influence of yeast-derived 1,3/1,6 glucopolysaccharide on circulating cytokines and chemokines with respect to upper respiratory tract infections

This 2012 randomized, double-blind, placebo-controlled trial evaluated the effects of daily supplementation with 250 mg of Wellmune WGP®, a yeast-derived 1,3/1,6 β-glucan, over 90 days in 100 healthy adults during peak upper respiratory tract infection (URTI) season. Participants recorded daily health logs, and URTI symptoms triggered medical assessments and blood

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June 26, 2025 No Comments

Innate Inflammation Induced by the 8-Oxoguanine DNA Glycosylase-1–KRAS–NF-κB Pathway

This study elucidates a novel mechanism by which the DNA repair enzyme 8-oxoguanine DNA glycosylase-1 (OGG1) contributes to innate inflammation. Upon repairing oxidatively damaged DNA (specifically 8-oxoG lesions), OGG1 forms a complex with the excised base, acquiring guanine nucleotide exchange factor activity that activates KRAS. Activated KRAS then triggers downstream

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June 26, 2025 No Comments