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Tag: KRAS

Innate Inflammation Induced by the 8-Oxoguanine DNA Glycosylase-1–KRAS–NF-κB Pathway

This study elucidates a novel mechanism by which the DNA repair enzyme 8-oxoguanine DNA glycosylase-1 (OGG1) contributes to innate inflammation. Upon repairing oxidatively damaged DNA (specifically 8-oxoG lesions), OGG1 forms a complex with the excised base, acquiring guanine nucleotide exchange factor activity that activates KRAS. Activated KRAS then triggers downstream

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June 26, 2025 No Comments

Revisiting Vitamin C and Cancer

This article provides an overview of recent research into the role of vitamin C in cancer therapy. It discusses the dual nature of vitamin C as both an antioxidant and a pro-oxidant, depending on its concentration and the cellular context. The review highlights studies that have shown high-dose vitamin C

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June 26, 2025 No Comments

Targeting Autophagy in Cancer: Recent Advances and Future Directions

This 2019 review outlines the complex role of autophagy in cancer, acting as both a tumor suppressor and a survival mechanism for established malignancies. It examines the latest research on autophagy inhibition as a therapeutic strategy, especially in cancers with mutations in KRAS and p53, which rely on autophagy for

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June 26, 2025 No Comments