This review explores the role of oxidative nucleic acid damage biomarkers, specifically 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoG), in disease detection and drug development. Elevated levels of these biomarkers, found at 1.3 to 5 times higher in patients than controls, have been linked to various diseases, including cancer, neurodegenerative disorders, and
