This 2016 review by Zanardi et al. explores the dual nature of ozone (O₃) as both a potent oxidant and a therapeutic agent. The authors discuss how, at controlled doses, ozone can stimulate beneficial biological responses, including the activation of antioxidant systems and modulation of the immune response. The review
This article discusses the pleiotropic effects of alpha-lipoic acid (ALA) and its potential therapeutic applications in diabetes and other chronic diseases. The study highlights ALA’s role as an antioxidant, improving insulin sensitivity, reducing inflammation, and combating oxidative stress. Additionally, ALA has shown promise in managing complications of diabetes, such as
This 2024 review explores the potential of vaccines to address aging and associated chronic diseases. It discusses strategies targeting specific antigens linked to conditions such as Alzheimer’s disease, type II diabetes, hypertension, abdominal aortic aneurysm, atherosclerosis, osteoarthritis, fibrosis, and cancer. Additionally, the article examines emerging vaccines aimed at eliminating senescent
This 2015 review by Sánchez et al. discusses the dual antioxidant and anti-inflammatory roles of melatonin in combating oxidative stress. Melatonin not only scavenges reactive oxygen and nitrogen species directly but also stimulates antioxidant enzymes like superoxide dismutase, glutathione peroxidase, and catalase. Due to its amphiphilic properties, melatonin effectively crosses
This review article explores the therapeutic potential of medical ozone therapy in modulating oxidative stress across a range of chronic diseases, including diabetes, cardiovascular conditions, and neurodegenerative disorders. It details ozone’s biochemical mechanisms—such as stimulating antioxidant enzymes, reducing inflammation, and modulating immune responses—and compiles findings from various studies showing symptomatic
This systematic review evaluates the health benefits and safety of resveratrol, a polyphenolic compound found in plants, based on over 244 clinical trials. Resveratrol has shown promise in improving outcomes for a variety of chronic conditions, including diabetes, obesity, certain cancers, metabolic syndrome, hypertension, Alzheimer’s disease, stroke, cardiovascular diseases, kidney
This 2025 review article published in Physiology (Bethesda) (DOI: 10.1152/physiol.00021.2024) explores low-grade chronic inflammation (LGCI) as a central mechanism underlying a wide range of chronic diseases, including obesity, cardiovascular conditions, digestive disorders, and cancer. It explains that unresolved or persistent inflammatory stimuli can result in LGCI, which in turn promotes
This review article explores how environmental and biological factors—such as pollution, poor nutrition, oxidative stress, and psychosocial stress—contribute to “inflammaging,” a chronic low-grade inflammatory state associated with aging. While genetic predisposition plays a minor role, the authors highlight that environmental exposures are key drivers of age-related inflammation and chronic diseases.
This review explores the role of oxidative nucleic acid damage biomarkers, specifically 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoG), in disease detection and drug development. Elevated levels of these biomarkers, found at 1.3 to 5 times higher in patients than controls, have been linked to various diseases, including cancer, neurodegenerative disorders, and
