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Tag: oxidative DNA damage

Active and passive smoking and lifestyle determinants of 8-oxo-7,8-dihydro-2′-deoxyguanosine levels in human leukocyte DNA

This observational study examined the impact of active and passive smoking on oxidative DNA damage by measuring 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) levels in leukocyte DNA. Findings revealed that active smokers exhibited significantly higher oxidative DNA damage compared to non-smokers, while passive smokers also had elevated levels, though to a lesser extent. Other

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June 26, 2025 No Comments

8-oxoguanine and 8-oxodeoxyguanosine Biomarkers of Oxidative DNA Damage: A Review on HPLC-ECD Determination

This systematic review examines the role of oxidative DNA damage biomarkers, specifically 8-oxoguanine and 8-oxodeoxyguanosine, and evaluates the effectiveness of high-performance liquid chromatography with electrochemical detection (HPLC-ECD) in their measurement. The findings highlight HPLC-ECD as a highly sensitive and specific technique for detecting oxidative DNA damage, offering advantages in precision

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June 26, 2025 No Comments

Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics

This study explores the role of urinary 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker for oxidative stress and its association with increased risks of cancer, atherosclerosis, and diabetes. Elevated urinary 8-OHdG levels were observed in patients with various cancers, human atherosclerotic plaques, and diabetic individuals with hyperglycemia, highlighting its potential as a

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June 26, 2025 No Comments

8-Hydroxy-2-Deoxyguanosine Levels and Cardiovascular Disease: A Systematic Review and Meta-Analysis of the Literature

This meta-analysis examined the association between 8-hydroxy-2-deoxyguanosine (8-OHdG) levels and cardiovascular disease (CVD), analyzing 14 studies with 810 CVD patients and 1,106 controls. Results showed significantly higher 8-OHdG levels in CVD patients compared to controls (standard mean difference: 1.04, 95% CI: 0.61–1.47, p < 0.001), with elevated levels observed in

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June 26, 2025 No Comments

Potential application of the oxidative nucleic acid damage biomarkers in detection of diseases

This review explores the role of oxidative nucleic acid damage biomarkers, specifically 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoG), in disease detection and drug development. Elevated levels of these biomarkers, found at 1.3 to 5 times higher in patients than controls, have been linked to various diseases, including cancer, neurodegenerative disorders, and

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June 26, 2025 No Comments

Cancer risk and oxidative DNA damage in man

This review explores the relationship between oxidative DNA damage and cancer risk in humans, highlighting how reactive oxygen species (ROS) contribute to DNA lesions that may lead to mutations and carcinogenesis. It discusses the body’s defense mechanisms against oxidative stress and the potential role of antioxidants in cancer prevention. The

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June 26, 2025 No Comments

Occupational and lifestyle factors and urinary 8-hydroxydeoxyguanosine

This observational study examined the impact of occupational and lifestyle factors on urinary 8-hydroxydeoxyguanosine (8-OHdG) levels, a biomarker of oxidative DNA damage. Findings indicated that individuals with specific occupational exposures to hazardous substances or certain lifestyle behaviors exhibited higher 8-OHdG concentrations, suggesting increased oxidative stress. Monitoring urinary 8-OHdG provides a

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June 26, 2025 No Comments

Effect of age, smoking and other lifestyle factors on urinary 7-methylguanine and 8-hydroxydeoxyguanosine

This observational study examined the effects of age, smoking, and other lifestyle factors on urinary levels of 7-methylguanine (m7G) and 8-hydroxydeoxyguanosine (8-OHdG), biomarkers of DNA methylation and oxidative DNA damage, respectively. Analyzing 215 healthy Japanese individuals, the study found that current smokers exhibited significantly higher urinary m7G levels (p <

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June 26, 2025 No Comments

Oxidative stress biomarkers and lifestyles in Japanese healthy people

This observational study investigated the relationship between lifestyle factors and oxidative stress biomarkers in 135 healthy Japanese adults aged 20 to 69 years. The findings showed that smokers had significantly higher urinary 8-hydroxydeoxyguanosine (8-OHdG) levels (p < 0.05), indicating increased oxidative DNA damage, while individuals who engaged in regular physical

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June 26, 2025 No Comments