Well Referenced

Tag: cancer

Hyperbaric oxygen therapy and cancer—a review

This 2012 review by Moen and Stuhr examines the effects of hyperbaric oxygen therapy (HBOT) on cancer progression, focusing on studies from 2004 to 2012. The authors found no evidence that HBOT stimulates tumor growth or recurrence. Instead, HBOT may inhibit tumor growth in certain cancer subtypes, such as breast

Read More »
June 26, 2025 No Comments

Link between Obesity and Cancer: Role of Triglyceride/Free Fatty Acid Cycling

This 2014 review explores the mechanistic links between obesity and cancer, focusing on the role of triglyceride/free fatty acid (TG/FFA) cycling. Obesity-induced alterations in lipid metabolism lead to increased availability of FFAs, which can promote tumorigenesis through various pathways, including enhanced energy supply for rapidly proliferating cancer cells, modulation of

Read More »
June 26, 2025 No Comments

The effects of metformin on autophagy

This 2021 review article explores the multifaceted role of metformin in modulating autophagy across various biological systems. Metformin primarily induces autophagy through activation of AMP-activated protein kinase (AMPK), leading to inhibition of the mTOR pathway. It also influences other signaling pathways, including AMPK/CEBPD, MiTF/TFE, AMPK/ULK1, and AMPK/miR-221. Additionally, metformin can

Read More »
June 26, 2025 No Comments

Prevalence of exposure of heavy metals and their impact on health consequences

This 2018 review highlights the significant health risks associated with heavy metal contamination in drinking water, focusing on metals such as arsenic, cadmium, nickel, mercury, chromium, zinc, and lead. Despite technological advancements, concentrations of these metals often exceed recommended safety limits globally. The primary exposure route is through the consumption

Read More »
June 26, 2025 No Comments

Angiogenesis and lead (Pb): is there a connection?

This review explores the potential link between lead (Pb) exposure and angiogenesis, the process of new blood vessel formation. Epidemiological and experimental studies suggest that Pb exposure may disrupt the regulation of angiogenic factors, particularly vascular endothelial growth factor (VEGF), leading to either excessive or insufficient angiogenesis. Such dysregulation is

Read More »
June 26, 2025 No Comments

Role of Glutathione in Cancer: From Mechanisms to Therapies

This 2020 review explores the complex role of glutathione (GSH) in cancer, emphasizing its dual nature as both a protector against oxidative stress and a contributor to tumor progression and drug resistance. Elevated GSH levels in cancer cells enhance survival, proliferation, and resistance to chemotherapy by detoxifying reactive oxygen species

Read More »
June 26, 2025 No Comments

Serious adverse events reported in placebo randomised controlled trials of oral naltrexone: a systematic review and meta-analysis

This systematic review and meta-analysis evaluated the safety profile of oral naltrexone by analyzing serious adverse events (SAEs) reported in placebo-controlled randomized controlled trials (RCTs). A total of 89 RCTs involving 11,194 participants across various conditions—including alcohol use disorders, psychiatric disorders, impulse control disorders, obesity, Crohn’s disease, fibromyalgia, and cancer—were

Read More »
June 26, 2025 No Comments

The role of nutraceutical proteins and peptides in apoptosis, angiogenesis, and metastasis of cancer cells

This review article explores the potential of nutraceutical proteins and peptides in cancer prevention and therapy. It examines biologically active compounds such as plant protease inhibitors, lactoferrin, lactoferricin, shark cartilage, plant lectins, and lunasin for their ability to modulate cancer cell behavior. Key mechanisms include the induction of apoptosis through

Read More »
June 26, 2025 No Comments