The bioidentical hormone debate: are bioidentical hormones (estradiol, estriol, and progesterone) safer or more efficacious than commonly used synthetic versions in hormone replacement therapy?

A review published in Postgraduate Medicine examined the safety and efficacy of bioidentical hormones (progesterone, estradiol, and estriol) compared to synthetic and animal-derived hormones used in hormone replacement therapy (HRT). The study found that patients reported greater satisfaction with HRT containing bioidentical progesterone over synthetic progestins. Clinical and physiological data