endocrinology Archives - Well Referenced

Effects of long-term testosterone therapy on patients with “diabesity”: results of observational studies of pooled analyses in obese hypogonadal men with type 2 diabetes

This pooled analysis of two prospective observational registry studies evaluated the long-term effects of testosterone undecanoate therapy in 156 obese hypogonadal men with type 2 diabetes mellitus (T2DM) over a period of up to 6 years. Testosterone treatment led to significant and sustained reductions in weight (mean loss of 17.49

June 26, 2025 No Comments

Does growth hormone replacement therapy reduce mortality in adults with growth hormone deficiency? Data from the Dutch National Registry of Growth Hormone Treatment in adults

This nationwide cohort study from the Netherlands analyzed the impact of growth hormone (GH) replacement therapy on mortality in adults with GH deficiency (GHD). The study included 2,229 GH-treated patients, 109 untreated patients, and 356 partially treated patients. Results showed that GH-treated men had mortality rates comparable to the general

June 26, 2025 No Comments

Socioeconomic factors do not but GH treatment does affect mortality in adult-onset growth hormone deficiency

This nationwide registry study from Denmark investigated the impact of socioeconomic factors and growth hormone (GH) treatment on mortality in adults with adult-onset GH deficiency. The study included 276 patients with GH deficiency and 25,717 matched controls. Results indicated that GH-treated patients exhibited reduced all-cause and malignancy-related mortality compared to

June 26, 2025 No Comments

Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog

This study investigated the effects of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, on growth hormone (GH) secretion in healthy men. Participants were given a single subcutaneous injection of CJC-1295 at doses of 60 or 90 µg/kg. GH secretion was measured over 12 hours before and one week after

June 26, 2025 No Comments

Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society Clinical Practice Guideline

This guideline provides comprehensive recommendations for diagnosing and managing adult growth hormone deficiency (GHD). It emphasizes that GHD can be congenital or acquired, often due to pituitary or hypothalamic lesions. Diagnosis typically requires stimulation testing, as random GH and IGF-1 levels are insufficient. GH replacement therapy is indicated for adults

June 26, 2025 No Comments

Body composition and quality of life in adults with growth hormone deficiency; effects of low-dose growth hormone replacement

This prospective, open-label study evaluated the early effects of low-dose growth hormone replacement (GHR) on body composition and quality of life (QoL) in adults with growth hormone deficiency (AGHD). Patients received daily GH doses of 0.4–0.5 IU, titrated to maintain IGF-I levels between the median and upper end of the

June 26, 2025 No Comments

Growth Hormone and Aging: Updated Review

This review examines the complex role of growth hormone (GH) in mammalian aging. While GH levels decline with age, this reduction may serve as a protective mechanism against age-related diseases, including cancer. Animal studies demonstrate that absence of GH signaling can extend lifespan, suggesting a deceleration of aging processes. In

June 26, 2025 No Comments

GH deficiency in patients with spinal cord injury: efficacy/safety of GH replacement, a pilot study

This pilot study assessed the prevalence of growth hormone deficiency (GHD) in individuals with chronic thoracic complete spinal cord injury (SCI) and evaluated the safety and efficacy of GH replacement therapy. Among 19 patients, 13 were identified with GHD. These patients were randomized to receive either GH therapy or placebo

June 26, 2025 No Comments

Growth hormone in the aging male

This review evaluates the effects of growth hormone (GH) supplementation in aging men, noting that GH and IGF-1 levels decline with age, leading to changes in body composition and function. Controlled studies indicate that GH therapy modestly increases lean body mass by approximately 2 kg and reduces fat mass similarly.

June 26, 2025 No Comments

Growth hormone and aging: a challenging controversy

This review explores the controversial role of growth hormone (GH) in aging. While GH levels naturally decline with age and GH therapy has been proposed for anti-aging, evidence suggests reduced GH/IGF-1 activity is associated with increased lifespan and decreased cancer risk in animal models. Human studies on GH therapy in

June 26, 2025 No Comments

Tag: endocrinology