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Tag: Synthetic Progestins

The bioidentical hormone debate: are bioidentical hormones (estradiol, estriol, and progesterone) safer or more efficacious than commonly used synthetic versions in hormone replacement therapy?

A review published in Postgraduate Medicine examined the safety and efficacy of bioidentical hormones (progesterone, estradiol, and estriol) compared to synthetic and animal-derived hormones used in hormone replacement therapy (HRT). The study found that patients reported greater satisfaction with HRT containing bioidentical progesterone over synthetic progestins. Clinical and physiological data

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June 26, 2025 No Comments

Menopausal Hormone Therapy Formulation and Breast Cancer Risk

This cohort study analyzed the relationship between different formulations of menopausal hormone therapy (HT) and breast cancer risk, finding that estrogen-only therapies (both bioidentical and animal-derived) did not significantly increase breast cancer risk, while synthetic progestins were more strongly associated with an increased risk. The study highlights a 12% increased

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June 26, 2025 No Comments

Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort

This observational study from the E3N-EPIC cohort investigated the relationship between various hormone replacement therapy (HRT) regimens and breast cancer risk. The study found that combining estrogens with synthetic progestins increased breast cancer risk, even for short durations, while transdermal estrogens with synthetic progestins also showed an elevated risk. However,

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June 26, 2025 No Comments