Efficacy of combined ozone and platelet-rich-plasma treatment versus platelet-rich-plasma treatment alone in early stage knee osteoarthritis

This 2019 retrospective study compared the outcomes of intra-articular platelet-rich plasma (PRP) injections alone versus PRP combined with ozone therapy in patients with early-stage knee osteoarthritis (KOA). The study included 80 patients—45 received PRP alone, and 35 received PRP plus ozone. Both groups exhibited significant improvements in pain (VAS) and